Endoscopic ultrasound-guided fine-needle aspiration when combined with positron emission tomography improves specificity and overall diagnostic accuracy in unexplained mediastinal lymphadenopathy and staging of non-small-cell lung cancer

Internal Medicine Journal
A V KaladeR Chen

Abstract

The aim of this study was to assess the incremental value of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) to positron emission tomography (PET) in the diagnosis of unexplained mediastinal lymphadenopathy and staging of non-small-cell lung cancer (NSCLC). Patients who had both EUS-guided FNA and PET were retrospectively identified from an EUS database at a tertiary hospital. All EUS-guided FNA were carried out by one endoscopist between August 2002 and April 2005, either for the diagnosis of unexplained mediastinal lymphadenopathy or for the staging of NSCLC. Results of PET and EUS were compared with histology. A true histological positive result was defined as histological involvement in either surgery (mediastinoscopy or resection) or EUS-guided FNA. A true histological negative result was defined as negative involvement at surgery (mediastinoscopy or resection). Forty-nine patients who had both PET scanning and EUS-guided FNA for diagnosis of unexplained mediastinal lymphadenopathy or staging of NSCLC were identified. Of these, 33 (73% males, n = 24, age range = 44-78 years, mean = 62 years) had surgical confirmation of mediastinal lymph node pathology. In these patients, PET alone showed sensitivity, 95%; ...Continue Reading

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Citations

Jul 28, 2010·Clinical Medicine & Research·Adedayo A OnitiloThanh Cuong T Nguyen
Jan 8, 2013·World Journal of Gastrointestinal Endoscopy·Benjamin TharianAlberto Larghi
Apr 13, 2012·Journal of Vascular and Interventional Radiology : JVIR·Nadine Abi-JaoudehBradford J Wood
Sep 12, 2009·Best Practice & Research. Clinical Gastroenterology·Peter VilmannPaul Clementsen
Mar 17, 2015·Seminars in Radiation Oncology·Michael MacManusRodney J Hicks
Apr 2, 2015·PET Clinics·Tim AkhurstRodney J Hicks
Jan 23, 2015·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jason CallahanRodney J Hicks

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