Endoscopic ultrasound-guided fine needle aspiration of pancreatic masses: the utility and impact on management of patients

Scandinavian Journal of Gastroenterology
Martin KlimentFrantisek Jaluvka

Abstract

It is controversial whether endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is beneficial in all patients with suspected pancreatic cancer. The aim of this study was to assess diagnostic yield, safety and impact of EUS-FNA on management of patients with solid pancreatic mass. Consecutive patients undergoing EUS-FNA of solid pancreatic mass were enrolled. Gold standard for final diagnosis included histology from surgical resection. In patients without surgery, clinical evaluation methods and repeated imaging studies were used for the comparison of initial cytology and final diagnosis. Patients were followed-up prospectively focusing on subsequent treatment. Among 207 enrolled patients, final diagnosis was malignant in 163 (78.6%) and benign in 44 (21.4%). The sensitivity, specificity and accuracy of EUS-FNA in diagnosing pancreatic cancer were 92.6% (95% CI: 87.20-95.96), 88.6% (95% CI: 74.64-95.64) and 91.8% (95% CI: 87.24-94.81), respectively. No major and five (2.4%) minor complications occurred. Of 151 true-positive patients by EUS-FNA, 57 (37.7%) were surgically explored, of whom 28 (49.1%) underwent resection. Ten of 12 patients with false-negative cytology were explored based on detection of mass on EUS, of ...Continue Reading

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Citations

Jul 4, 2012·Journal of Cancer Research and Clinical Oncology·Jiong ChenHangcheng Zhou
Nov 13, 2013·Gastrointestinal Endoscopy Clinics of North America·Larissa L Fujii, Michael J Levy
May 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ge ChenTaiping Zhang
Jun 26, 2012·Gastrointestinal Endoscopy·Nathaniel RanneyShyam Varadarajulu
May 20, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Bo SunZhaozhen Zhang
Jan 1, 2011·Cancers·Emanuele DabizziMassimo Raimondo
Apr 18, 2017·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Aug 28, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Moon Jae ChungJoo Young Cho

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