Endoscopic ultrasound in the evaluation of gastric small lymphocytic mucosa-associated lymphoid tumors

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A C PavlickC S Portlock

Abstract

Low-grade, small lymphocytic lymphomas of the mucosa-associated lymphoid tissue (MALT) have recently been shown to be associated with Helicobacter pylori infections. Regression of these tumors has been reported with antibiotic therapy. Here we evaluate endoscopic ultrasound (EUS) as on objective method to evaluate pretreatment disease and posttherapy response. We retrospectively reviewed 20 patients initially diagnosed elsewhere with MALT lymphoma. All patients had their initial endoscopic biopsies (EGDs) reviewed at Memorial Sloan-Kettering Cancer Center (MSKCC). All patients had EUS performed at the time of consultation and on completion of therapy if treated at our center. Antral biopsies were stained with a modified Steiner preparation to determine infection by H pylori. Gastric low-grade lymphoma was confirmed in 16 of 20 patients; 11 of 16 had previously received antibiotic therapy for biopsy-positive H pylori infection. All gastric lymphomas had an abnormal EUS: eight with discrete tumor masses and eight with gastric wall infiltration (submucosa, n = 4; muscularis propria, n = 3; serosa, n = 1). On completion of lymphoma treatment with chemotherapy, radiotherapy, or surgery, 11 of 16 patients underwent follow-up EUS. Fiv...Continue Reading

Citations

Oct 2, 2001·Journal of Clinical Ultrasound : JCU·M GavioliG Natalini
Sep 25, 2002·Alimentary Pharmacology & Therapeutics·G CalettiUNKNOWN Italian Gastric Lymphona Study Group
Dec 23, 2011·Hematological Oncology·Calogero VetroFrancesco Di Raimondo
Oct 4, 2014·World Journal of Gastroenterology : WJG·Calogero VetroFrancesco Di Raimondo
Nov 28, 2001·Hematology·F CavalliE Zucca
Feb 20, 2007·ANZ Journal of Surgery·Grant R Caddy, Robert Y Chen
Aug 24, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Hui-Ju WangHou-Quan Tao
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Vanessa M Shami, Irving Waxman
Sep 16, 2003·Advances in Anatomic Pathology·Nirag Jhala, Darshana Jhala
Mar 23, 2011·Human Pathology·Hou-Quan TaoZhong-Sheng Zhao
Oct 27, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F Di RaimondoR Giustolisi

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