Endoscopic variceal ligation versus propranolol in prophylaxis of first variceal bleeding in patients with cirrhosis

Journal of Gastroenterology and Hepatology
Chii-Shyan LayCheng-Yuan Peng

Abstract

To compare the efficacy and safety of endoscopic variceal ligation (EVL) with propranolol in prophylaxis on the rate of first esophageal variceal bleeding in patients with cirrhosis. A prospective, randomized trial was conducted in 100 cirrhotic patients with no history of previous upper gastrointestinal bleeding and with esophageal varices endoscopically judged to be at high risk of hemorrhage. The end-points of the study were bleeding and death. Life-table curves showed that prophylactic EVL and propranolol were similarly effective for primary prophylaxis of variceal bleeding (11/50 [22%]vs 12/50 [24%]; P = 0.68) and overall mortality (14/50 [28%]vs 12/50 [24%]; P = 0.49). The 2-year cumulative bleeding rate was 18% (9/50) in the EVL group and 16% (8/50) in the propranolol group. The 2-year cumulative mortality rate was 28% (14/50) in the EVL group and 24% (12/50) in the propranolol group. Comparison of Kaplan-Meier estimates of the time to death of both groups showed no significant difference in mortality in both groups (P = 0.86). Patients undergoing EVL had few treatment failures and died mainly of hepatic failure. In the propranolol group, the mean daily dosage of the drug was 68.2 +/- 32.8 mg, which was sufficient to red...Continue Reading

References

Jun 4, 1992·The New England Journal of Medicine·G V StiegmannS R Lowenstein
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y T TsaiK J Lo
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K J Paquet, H Feussner
Jan 1, 1972·Medicine·H O ConnG R Ramsby
Aug 1, 1982·The Journal of Infectious Diseases·K J LoS D Lee
Nov 1, 1981·Gastrointestinal Endoscopy·K BeppuM Kobayashi
Apr 1, 1999·The New England Journal of Medicine·S K SarinN S Murthy
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T F Imperiale, N Chalasani
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D Lebrec
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D R AbraczinskasH O Conn
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan G AbraldesJaime Bosch
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan Carlos García-PagánUNKNOWN Spanish Variceal Bleeding Study Group
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael SchepkeUNKNOWN German Study Group for the Primary Prophylaxis of Variceal Bleeding

❮ Previous
Next ❯

Citations

Sep 1, 2007·Hepatology International·Shiv Kumar SarinUNKNOWN Members of the APASL Working Party on Portal Hypertension
Aug 12, 2009·Hepatology International·Shiv Kumar SarinUNKNOWN APASL Working Party on Portal Hypertension
Jun 5, 2007·Current Opinion in Gastroenterology·Roberto de Franchis, Alessandra Dell'Era
Jan 16, 2010·BMC Gastroenterology·Florian PetraschAlbrecht Hoffmeister
Jul 19, 2013·World Journal of Gastroenterology : WJG·De-Run KongJian-Ming Xu
May 12, 2012·International Journal of Hepatology·Yen-I Chen, Peter Ghali
Dec 19, 2013·North American Journal of Medical Sciences·Zeid Karadsheh, Harmony Allison
Jul 19, 2014·Gastrointestinal Endoscopy·Joo Ha HwangUNKNOWN American Society for Gastrointestinal Endoscopy
Apr 1, 2014·Clinics in Liver Disease·Douglas A SimonettoPatrick S Kamath
Jul 18, 2012·Seminars in Pediatric Surgery·Jean de Ville de GoyetChiara Grimaldi
Oct 29, 2011·Clinics in Liver Disease·Hui-Hui Tan, Paul Martin
May 16, 2009·Clinics in Liver Disease·Priya Grewal, Paul Martin
May 6, 2008·Gastroentérologie Clinique Et Biologique·P BellotJ Bosch
Mar 19, 2008·Best Practice & Research. Clinical Gastroenterology·F H Klebl, J Schölmerich
Feb 23, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C TianiJ Bosch
Jan 16, 2007·Best Practice & Research. Clinical Gastroenterology·Christos K Triantos, Andrew K Burroughs
Jan 13, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Maja ThieleAleksander Krag
Jul 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dhiraj TripathiPeter C Hayes
Sep 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Oct 16, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Chunqing ZhangVijay H Shah
Dec 7, 2010·Journal of the American Academy of Nurse Practitioners·Tammy Tursi
Oct 19, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Dhiraj Tripathi, Peter C Hayes
Apr 20, 2010·Journal of Hepatology·Andrew K BurroughsChristos Triantos
Feb 29, 2008·Journal of Hepatology·Jaime BoschJuan G Abraldes
Jun 2, 2016·Journal of Gastroenterology·Hiroshi FukuiTooru Shimosegawa
Sep 8, 2010·The American Journal of Gastroenterology·Puneeta TandonJaime Bosch
Sep 3, 2013·Therapeutic Advances in Chronic Disease·Johanne BrooksIan L P Beales
Jun 21, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Jonathan G StinePatrick G Northup
Nov 29, 2007·The American Journal of Gastroenterology·Lise L GluudChristian Gluud
Aug 31, 2007·The American Journal of Gastroenterology·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of American College of Gastroenterology
Sep 18, 2007·European Journal of Gastroenterology & Hepatology·Dhiraj TripathiPeter C Hayes
Aug 21, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mayank SharmaDouglas A Simonetto
Sep 18, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chang Hyeong Lee
Dec 6, 2007·Journal of Clinical Gastroenterology·Agustín Albillos
Aug 4, 2010·Expert Review of Gastroenterology & Hepatology·Dhiraj Tripathi
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Lise Lotte Gluud, Aleksander Krag
Mar 15, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Gautam Ray
Apr 7, 2021·The Cochrane Database of Systematic Reviews·Davide RoccarinaKurinchi Selvan Gurusamy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Michael SchepkeGerman Study Group for the Primary Prophylaxis of Variceal Bleeding
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Lorenzo NorbertoDavide F D'Amico
© 2021 Meta ULC. All rights reserved