Endoscopic visualization of cancer and dysplasia in patients with ulcerative colitis following sensitization with oral 5-aminolevulinic acid.

Journal of Digestive Diseases
Tomohiro KatoMasayuki Saruta

Abstract

Early diagnosis of colitis-associated cancer and dysplasia through surveillance endoscopy is vital for patients with ulcerative colitis (UC). This study aimed to evaluate the efficacy of autofluorescence endoscopy (AFE) using 5-aminolevulinic acid (ALA) and to investigate the fluorescence signal localization pattern following 5-ALA administration in tumorous lesions diagnosed as colitis-associated cancer and dysplasia. The sensitivity and specificity of tumorous lesions detected by white light endoscopy (WLE) with and without AFE were evaluated. Overall, 13 endoscopic procedures were performed in 11 patients with UC using WLE and AFE following the oral administration of 5-ALA. The biopsied lesions detected via endoscopy and resected specimens from cases underwent colectomy were assessed histopathologically. The sensitivity and specificity of detecting tumorous lesions by WLE with and without AFE were evaluated. Of the 68 lesions detected and biopsied, 63 were detected via WLE, and five were detected via AFE alone. The sensitivity of detecting colitis-associated cancer and dysplasia via WLE combined with AFE was 36.4%, and the specificity, positive predictive value and negative predictive value were 94.2%, 57.1%, and 87.5%, resp...Continue Reading

References

Nov 1, 1990·The New England Journal of Medicine·A EkbomH O Adami
Jun 30, 1994·The New England Journal of Medicine·S LichtigerS Hanauer
Feb 3, 2004·Gastroenterology·Keisuke HataHirokazu Nagawa
Sep 6, 2006·Gastroenterology Clinics of North America·Steven H Itzkowitz
Dec 22, 2007·European Urology·Dieter JochamRaphaela Waidelich
Jul 24, 2008·The American Journal of Gastroenterology·Takahisa MatsudaDaizo Saito
Jan 1, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T MatsumotoM Iida
Dec 16, 2011·World Journal of Gastroenterology : WJG·Taro OsadaSumio Watanabe
Feb 1, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tine JessLaurent Peyrin-Biroulet
Aug 1, 2013·Inflammatory Bowel Diseases·Marios EfthymiouMichael A Kamm
Mar 13, 2014·Alimentary Pharmacology & Therapeutics·C Castaño-MillaJ P Gisbert
Feb 25, 2015·Gastrointestinal Endoscopy·Loren LaineUNKNOWN SCENIC Guideline Development Panel
Aug 13, 2015·International Journal of Colorectal Disease·Kentaro MoriichiYutaka Kohgo
Apr 18, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Keisuke KawasakiTakayuki Matsumoto

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Methods Mentioned

BETA
biopsy
biopsies
fluorescence imaging

Software Mentioned

STATA

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