PMID: 9653475Jul 8, 1998Paper

Endoscopically guided frontal sinus beclomethasone instillation for refractory frontal sinus/recess mucosal edema and polyposis

American Journal of Rhinology
Martin J Citardi, F A Kuhn

Abstract

Despite its metabolic complications, systemic corticosteroid therapy remains a mainstay in the treatment of refractory polyposis after endoscopic frontal sinusotomy. Furthermore, topical nasal corticosteroids often fail, presumably due to the relatively small dosage actually absorbed by the polyps. In order to minimize steroid complications while increasing the locally absorbed dose, beclomethasone (approximately 1 cc, 84 mcg/100 microliters) was instilled under endoscopic guidance directly into the frontal sinus in 31 instances in 16 patients with postoperative frontal recess/sinus polyposis and mucosal edema. The frontal recess/sinus polyposis/edema resolved completely in 9 frontal sinuses, improved considerably in 7 frontal sinuses, improved minimally in 5 frontal sinuses, and remained unchanged in 10 frontal sinuses. No complications were noted. AM cortisol levels remained in the normal range. Endoscopically guided frontal sinus beclomethasone instillation should be considered for the treatment of refractory postoperative frontal sinus/recess polyposis/edema. Further basic and clinical research into the pathophysiology of the nasal mucosa is also warranted.

References

Feb 1, 1987·The Journal of Laryngology and Otology·S P NewmanS W Clarke

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Citations

Apr 4, 2006·Current Allergy and Asthma Reports·Pete S Batra
May 10, 2001·Otolaryngologic Clinics of North America·M Maccabee, P H Hwang
May 10, 2001·Otolaryngologic Clinics of North America·R R Orlandi, D W Kennedy
Jul 6, 2010·Otolaryngologic Clinics of North America·Bruce K Tan, Rakesh K Chandra
Nov 17, 2009·Otolaryngologic Clinics of North America·Richard J Harvey, Rodney J Schlosser
Jan 31, 2009·American Journal of Rhinology·Amber LuongMartin J Citardi
Dec 22, 2006·American Journal of Rhinology·John M DelGaudio, Sarah K Wise
Feb 15, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yu-Xiao WuCong-Li Geng
Dec 29, 2020·Ear, Nose, & Throat Journal·Derek B WuKevin C Welch

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