Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non-endosomal functions

Cancer Science
Nobuyuki TanakaKazuo Sugamura

Abstract

Endosomal sorting complex required for transport (ESCRT) proteins form a multicomplex sorting machinery that controls multivesicular body (MVB) formation and the sorting of ubiquitinated membrane proteins to the endosomes. Being sorted to the MVB generally results in the lysosome-dependent degradation of cell-surface receptors, and defects in this machinery induce dysregulated receptor traffic and turnover. Recent lessons from gene targeting and silencing methodologies have implicated the ESCRT in normal development, cell differentiation, and growth, as well as in the budding of certain enveloped viruses. Furthermore, it is becoming apparent that the dysregulation of ESCRT proteins is involved in the development of various human diseases, including many types of cancers and neurodegenerative disorders. Here, we summarize the roles of ESCRT proteins in MVB sorting processes and the regulation of tumor cells, and we discuss some of their other functions that are unrelated to vesicular transport.

References

Apr 1, 1997·Immunology Today·A M Weissman
Aug 15, 2000·The Journal of Biological Chemistry·L QiuY C Liu
Nov 30, 2000·Molecular and Cellular Biology·S MiuraK Sugamura
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L LiS N Cohen
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·J RulandT W Mak
Mar 27, 2001·Nature Reviews. Molecular Cell Biology·L Hicke
May 8, 2001·Molecular and Cellular Biology·M YamadaK Sugamura
Jun 23, 2001·Oncogene·D E HammondM J Clague
Jan 31, 2002·Current Biology : CB·Eric C Lai
Feb 12, 2002·Nature Cell Biology·Yasuyuki FujitaWalter Birchmeier
May 4, 2002·Nature Cell Biology·Camilla RaiborgHarald Stenmark
Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
Aug 21, 2002·Trends in Cell Biology·F Gisou van der Goot, Jean Gruenberg
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taher E I TaherSteven T Pals
Nov 26, 2002·Molecular and Cellular Biology·Mitsuhiro YamadaKazuo Sugamura
Dec 4, 2002·Nature Reviews. Molecular Cell Biology·David J KatzmannScott D Emr
Dec 17, 2002·Molecular and Cellular Biology·Kay-Uwe WagnerLothar Hennighausen
Mar 26, 2003·Annual Review of Biochemistry·Juan S Bonifacino, Linton M Traub
Apr 11, 2003·Molecular Biology of the Cell·Dean E HammondMichael J Clague
Apr 30, 2003·Nature Cell Biology·Kaisa HaglundIvan Dikic
Jul 9, 2003·The Journal of Cell Biology·Wei SunAndrew J Bean
Aug 2, 2003·Current Opinion in Cell Biology·Camilla RaiborgHarald Stenmark
Aug 6, 2003·The Journal of Cell Biology·David J KatzmannScott D Emr
Aug 6, 2003·The Journal of Cell Biology·Kristi G BacheHarald Stenmark
Aug 19, 2003·Nature Reviews. Molecular Cell Biology·Stefan GrünertHartmut Beug
Sep 19, 2003·Biochemical and Biophysical Research Communications·Chikako KanazawaKazuo Sugamura
Sep 25, 2003·Cell·Uta K von SchwedlerWesley I Sundquist
Oct 23, 2003·Nature Reviews. Cancer·Freddy Radtke, Kenneth Raj

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Citations

Jun 10, 2010·The Journal of Biological Chemistry·Nakako Shibagaki, Arthur R Grossman
Mar 21, 2012·The Journal of Biological Chemistry·David LutzRalf Kleene
Aug 14, 2012·Molecular & Cellular Proteomics : MCP·Henning SievertStefan Balabanov
Aug 13, 2010·Molecular Biology of the Cell·Brian A DaviesDavid J Katzmann
Mar 15, 2012·Science Signaling·Ben BrankatschkJean Gruenberg
Feb 26, 2013·The Journal of Clinical Investigation·Shunsuke KonMasanobu Satake
Mar 5, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tsutomu Takahashi
Jun 9, 2012·PloS One·Hillary K GravesAndreas Bergmann
Jul 6, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Takehiro MiyazakiToshinobu Tokumoto
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Maxence V NachuryHua Jin
Feb 27, 2009·Chemical Reviews·Brian A DaviesDavid J Katzmann
Jan 10, 2009·Experimental Cell Research·Thomas FalguièresJean Gruenberg
Jul 17, 2012·Trends in Cell Biology·Máté PálfyTamás Korcsmáros
Jul 7, 2009·Molecular Oncology·Beata PyrzynskaMarta Miaczynska
Nov 20, 2013·Biochemical and Biophysical Research Communications·Takayuki NagataNaoto Ishii
May 14, 2016·Journal of Neurovirology·Pejman Rahimian, Johnny J He
Apr 10, 2009·Carcinogenesis·Emanuela MatteucciMaria Alfonsina Desiderio
Jan 16, 2009·Biochemical Society Transactions·Lina M RodahlHarald Stenmark
Sep 15, 2019·The Journal of Biological Chemistry·Huxley K HoffmanSchuyler B van Engelenburg
Feb 15, 2019·International Journal of Molecular Sciences·Huey-Huey ChuaTe-Huei Yeh
Oct 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael WittingerMichael Krainer
Mar 7, 2021·Cells·Arianna CalistriCristina Parolin
Nov 16, 2011·Journal of Cell Science·Ciara Metcalfe, Mariann Bienz
May 1, 2021·International Journal of Molecular Sciences·Carmen Elena CondratSilviu Cristian Voinea
Apr 23, 2009·Cellular Signalling·Thomas Grewal, Carlos Enrich

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