Endostatin as a Mediator Between Endothelial Function and Cognitive Performance in Those at Risk for Vascular Cognitive Impairment.

Journal of Alzheimer's Disease : JAD
Cameron Isaacs-TrepanierKrista L Lanctôt

Abstract

Patients with coronary artery disease have an increased risk for developing vascular cognitive impairment. Endothelial function is often diminished and has been associated with lower cognitive performance in these patients. The link between endothelial function and cognition in coronary artery disease is not fully understood. Angiogenesis may play a role in mediating the association between endothelial function and cognition since angiogenic processes rely heavily on the endothelium. The aim of this study was to determine if markers of angiogenesis mediate the relationship between endothelial function and cognition in coronary artery disease patients. In 50 participants with coronary artery disease, endothelial function was assessed using peripheral arterial tonometry. Vascular endothelial growth factor (pro-angiogenic) and endostatin (anti-angiogenic) were measured in peripheral serum samples. Cognition was assessed using the Montreal Cognitive Assessment. A mediation analysis, using a bias corrected inferential bootstrapping method with 10,000 permutations, was used to determine if vascular endothelial growth factor or endostatin mediated an association between peripheral arterial tonometry measures and cognitive performance ...Continue Reading

References

Feb 15, 2001·The New England Journal of Medicine·M F NewmanUNKNOWN Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors Investigators
Jul 10, 2003·American Heart Journal·Jeffrey T KuvinJames E Udelson
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Reijo S TilvisTimo E Strandberg
Dec 8, 2004·Journal of the American College of Cardiology·Piero O BonettiAmir Lerman
Feb 14, 2006·Neurobiology of Aging·Angela L JeffersonRonald A Cohen
Jun 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shahar LaviGiris Jacob
Aug 19, 2006·Stroke; a Journal of Cerebral Circulation·Vladimir HachinskiGabrielle G Leblanc
Jan 6, 2007·Stroke; a Journal of Cerebral Circulation·Karin F HothRonald A Cohen
Apr 21, 2007·Psychological Science·Matthew S Fritz, David P Mackinnon
Apr 26, 2007·Anesthesia and Analgesia·Brendan S SilbertPaul T Maruff
Aug 23, 2007·Journal of the American Geriatrics Society·Didem Sener DedeServet Ariogul
Jul 22, 2010·Journal of the American Geriatrics Society·Walter SwardfagerKrista L Lanctôt
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Sep 8, 2011·The Journal of Biological Chemistry·Florian VeillardGilles Lalmanach
Dec 18, 2012·Cardiovascular Psychiatry and Neurology·Jack C de la Torre
Mar 19, 2014·Alzheimer Disease and Associated Disorders·Perminder SachdevUNKNOWN Internationlal Society for Vascular Behavioral and Cognitive Disorders
Mar 26, 2014·Nature Reviews. Cardiology·Nathan D Wong
Aug 12, 2014·Disease Markers·Catarina RamosTeresa Pinheiro
Dec 17, 2014·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Calvin SantiagoKrista L Lanctôt
Dec 17, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heather M SnyderMaria C Carrillo
Sep 27, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Kiran PrakashKishore K Deepak
Oct 16, 2015·Biochimie·Manu O Platt, W Andrew Shockey
Jan 1, 2017·International Journal of Cardiology·Thomas H OttensDiederik van Dijk
Feb 22, 2017·Parkinsonism & Related Disorders·Taylor R HendershottKathleen L Poston
May 17, 2017·Journal of Alzheimer's Disease : JAD·Ivonne SuridjanKrista L Lanctôt
Jul 13, 2017·Journal of Alzheimer's Disease : JAD·Emma BorlandSebastian Palmqvist

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Citations

Sep 26, 2021·Environmental Science and Pollution Research International·Dapinder KaurSimona Bungau

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Methods Mentioned

BETA
coronary artery bypass
ELISA

Software Mentioned

PAT
SPSS

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