Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points

ACS Chemical Neuroscience
Belén Gómez-GiménezVicente Felipo

Abstract

Exposure to pesticides has been associated with neurodevelopmental toxicity. Usually people are exposed to mixtures of pesticides. However, most studies analyze the effects of individual pesticides. Developmental exposure to mixtures of pesticides may result in additive effects or in antagonistic or synergistic effects. The aim of this work was to compare the effects of developmental exposure of rats to cypermethrin or endosulfan with the effects of its mixture on cognitive and motor function and on some underlying mechanisms. Exposure to individual pesticides or the mixture was from gestational day 7 to postnatal day 21. We analyzed the effects, in males and females, on spatial learning and memory, associative learning, anxiety, motor coordination, and spontaneous motor activity. We also analyzed neuroinflammation and NMDA receptor subunits in hippocampus and extracellular GABA in cerebellum. Exposure to the mixture, but not to individual pesticides, impaired spatial memory in males, associative learning in females, and increased motor activity in males and females. This indicates a synergistic effect of cypermethrin and endolsufan exposure on these end points. In contrast, motor coordination was impaired by individual exposur...Continue Reading

References

Apr 1, 1968·The Journal of Pharmacy and Pharmacology·B J Jones, D J Roberts
Jun 10, 1998·Environmental Health Perspectives·E A GuilletteI E Garcia
Mar 15, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·V C MoserR E Chapin
May 21, 2003·Human & Experimental Toxicology·Paulo R DalsenterEliane Dallegrave
Feb 8, 2005·Nature Neuroscience·H Jacob HancharMartin Wallner
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chi-Sung ChiuHenry A Lester
Apr 1, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·V C MoserC Gennings
Mar 17, 2006·Pharmacology, Biochemistry, and Behavior·Wei Xi KongXiaojuan Mi
Dec 16, 2006·Neurotoxicology and Teratology·Susan A LaessigEllen K Silbergeld
Jan 31, 2007·Biochemical and Biophysical Research Communications·Eun Hee HanHye Gwang Jeong
Dec 7, 2007·Toxicology Letters·Teresa CabaleiroAnunciación Lafuente
Jul 22, 2008·Brain, Behavior, and Immunity·Colm Cunningham, David J Sanderson
Mar 11, 2009·Physiology & Behavior·Christina Dalla, Tracey J Shors
Mar 17, 2009·Chemical Research in Toxicology·John E Casida
Oct 20, 2009·European Journal of Pharmacology·Christopher BarkusDavid M Bannerman
Jan 18, 2011·Environmental Science & Technology·Gila NetaRolf U Halden
Jul 2, 2011·Environmental Health Perspectives·Jordi JulvezPhilippe Grandjean
Sep 21, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Angela W CoronaJonathan P Godbout
Feb 22, 2014·Lancet Neurology·Philippe Grandjean, Philip J Landrigan
May 2, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·R IyyaduraiK P P Abhilash
Jun 11, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marieke MeijerRemco H S Westerink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved