Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia

Cell and Tissue Research
Samuel LiévanoLorenza González-Mariscal

Abstract

This study explores the molecular composition of the tight junction (TJ) in human term placenta from normal women and from patients with preeclampsia, a hypertensive disorder of pregnancy. Maternal endothelial dysfunction is a critical characteristic of preeclampsia; hence, we have analyzed its impact on placental vessels. The study concentrates on the TJ because this structure regulates the sealing of the paracellular route. We have found that, in placental endothelial vessels, TJ components include the peripheral protein ZO-1 and the integral proteins occludin and claudins 1, 3, and 5. During preeclampsia, the amounts of occludin and ZO-1 exhibit no significant variation, whereas those of claudins 1, 3, and 5 diminish, suggesting the presence of leakier TJs in the endothelia of the preeclamptic placenta, possibly in response to the decreased perfusion of this organ during preeclampsia. We have unexpectedly found that, in normal placentae, the multinucleated syncytiotrophoblast layer displays claudin 4 at the basal surface of the plasma membrane, and claudin 16 along the apical and basolateral surfaces. The presence of membrane-lined channels that cross the syncytiotrophoblast constituting a paracellular pathway has been deter...Continue Reading

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Citations

Dec 7, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Elina Pirinen, Ylermi Soini
Oct 27, 2007·Biochimica Et Biophysica Acta·Yann Wallez, Philippe Huber
Oct 24, 2007·Biochimica Et Biophysica Acta·Lorenza González-MariscalDavid Chamorro
Aug 21, 2013·Experimental Cell Research·Jesús Hernández-MongePatricio Gariglio
Jan 23, 2016·Biology of Reproduction·Violeta StojanovskaTorsten Plösch
Sep 9, 2016·Physiological Reviews·Graham J BurtonKent L Thornburg
Dec 12, 2017·Biology of Reproduction·Alison G PaquetteLouis J Muglia
Sep 26, 2013·Molecular Biology Reports·Yan-Jun HuWan-Xi Yang
Nov 5, 2020·Reproductive Sciences·Enoch Appiah Adu-GyamfiYing-Xiong Wang
Aug 22, 2008·Biomedical and Environmental Sciences : BES·Xiao-Wu WangGuo-Zhen Guo

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