Endothelial activation and repair during hantavirus infection: association with disease outcome

Open Forum Infectious Diseases
Anne-Marie Connolly-AndersenClas Ahlm

Abstract

Endothelial activation and dysfunction play a central role in the pathogenesis of sepsis and viral hemorrhagic fevers. Hantaviral disease is a viral hemorrhagic fever and is characterized by capillary dysfunction, although the underlying mechanisms for hantaviral disease are not fully elucidated. The temporal course of endothelial activation and repair were analyzed during Puumala hantavirus infection and associated with disease outcome and a marker for hypoxia, insulin-like growth factor binding protein 1 (IGFBP-1). The following endothelial activation markers were studied: endothelial glycocalyx degradation (syndecan-1) and leukocyte adhesion molecules (soluble vascular cellular adhesion molecule 1, intercellular adhesion molecule 1, and endothelial selectin). Cytokines associated with vascular repair were also analyzed (vascular endothelial growth factor, erythropoietin, angiopoietin, and stromal cell-derived factor 1). Most of the markers we studied were highest during the earliest phase of hantaviral disease and associated with clinical and laboratory surrogate markers for disease outcome. In particular, the marker for glycocalyx degradation, syndecan-1, was significantly associated with levels of thrombocytes, albumin, IG...Continue Reading

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Citations

Aug 11, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Andrea L ConroyKevin C Kain
Mar 18, 2015·British Journal of Clinical Pharmacology·Bernhard F BeckerDaniel Chappell
Mar 13, 2015·The Journal of Infectious Diseases·Anne-Marie Connolly-AndersenSofie Nilsson
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Nov 14, 2019·The Journal of Infectious Diseases·Clare M SchmedesAnne-Marie Fors Connolly
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Aug 3, 2021·Frontiers in Cell and Developmental Biology·Nuria VillalbaSarah Y Yuan
Aug 29, 2021·Viruses·Sirpa KoskelaOuti Laine

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS

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