PMID: 2499094Jan 1, 1989Paper

Endothelial basement membrane and seamless-type endothelium in the repair process of cerebral infarction in rats

Virchows Archiv. A, Pathological Anatomy and Histopathology
Y YoshidaT Kumanishi

Abstract

Ultrastructural analysis of capillary changes during the repair process of experimental cerebral infarction induced in rats was carried out with special reference to the endothelial basement membrane (BM) and seamless-type endothelial cells. Following degeneration of endothelial cells and pericytes, their BMs, without any interruption or fragmentation, were left in the lesion. Newly formed capillaries grew from vessels in the surrounding brain tissues into the reactive zone of infarcts. While the capillaries in cross-section possessed multilayered BMs, these membranes in tangential section comprised an outer BM with extremely wavy profile and an inner one showing a normal trilayered structure, uniformly enveloping the endothelial surface. It is therefore suggested that the sprouting of regenerating capillaries might invade the remaining cavities of BM, resulting from endothelial degeneration. In these new vessels, seamless-type endothelial cells lacking interendothelial contacts were observed frequently. These two different and previously unobserved findings appear to be at the heart of the regeneration mechanism of reactive capillary proliferation.

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Citations

Aug 1, 2009·Journal of Applied Physiology·Sirajedin S NatahJeff F Dunn
Dec 1, 1991·Journal of Neuroscience Research·L S PerlmutterH C Chui
Dec 11, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marta S Charpentier, Frank L Conlon
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z G ZhangM Chopp
Aug 9, 2003·Critical Care Medicine·Rhonda S FishelAdrian Barbul
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·Z G ZhangU Förstermann

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