Endothelial cell activation and neovascularization are prominent in dermatomyositis

Journal of Autoimmune Diseases
Kanneboyina NagarajuIngrid E Lundberg

Abstract

While vascular and immune abnormalities are common in juvenile and adult dermatomyositis (DM), the molecular changes that contribute to these abnormalities are not clear. Therefore, we investigated pathways that facilitate new blood vessel formation and dendritic cell migration in dermatomyositis. Muscle biopsies from subjects with DM (9 children and 6 adults) and non-myositis controls (6 children and 7 adults) were investigated by immunohistochemistry using antibodies that recognize existing (anti-CD146) and newly formed blood vessels (anti-alphaVbeta3) and mature dendritic cells (anti-DC-LAMP). Blood vessel quantification was performed by digitalized image analysis. Additional muscle biopsies from subjects with adult DM and non-myositis controls were used for global gene expression profiling experiments. A significant increase in neovascularization was found in muscle biopsies of DM patients; neovascularization (alphaVbeta3 positive capillaries and vessels per muscle fiber) was much higher in juvenile than in adult DM patients (control vs juvenile DM: Mean +/- SE: 0.06 +/- 0.01 vs 0.6 +/- 0.05; p < 0.0001 and control vs adult DM: Mean +/- SE: 0.60 +/- 0.1 vs 0.75 +/- 0.1; p = 0.051). Gene expression analysis demonstrated that...Continue Reading

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Citations

Sep 25, 2012·Rheumatology·Pernille R MathiesenSusan Nielsen
Jun 14, 2013·Skeletal Muscle·Sree RayavarapuKanneboyina Nagaraju
May 2, 2012·Arthritis Research & Therapy·William ColeyKanneboyina Nagaraju
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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

MAS
Axiovision
[UNK]
ProbeProfiler
dCHIP
GeneSpring
Affymetrix Microarray Suite
Affymetrix

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