Endothelial cell activation following moderate traumatic brain injury

Neurological Research
R BalabanovP Dore-Duffy

Abstract

Traumatic brain injury (TBI) initiates a cascade of acute and chronic injury responses which include disturbances in the cerebrovasculature that may result in the activation of the microvascular endothelial development of a dysfunction endothelium. The present study examines endothelial cell (EC) activation in a percussion model of moderate TBI. The criteria for endothelial activation used in these studies was surface expression of a number of markers collectively termed endothelial activation antigens. Temporal induction of the major histocompatibility (MHC) class II molecules, E-selectin (CD62E), vascular cell adhesion molecule (VACM-1) (CD106) as well as altered expression of constitutively expressed intercellular adhesion molecule-1 (ICAM-1) (CD54), the glucose transporter protein (glut-1), the transferrin receptor (tfR) (CD71), and MHC class I molecules was examined at various times following impact. Induction of E-selectin and increased expression of ICAM-1 was seen by 2 h post-impact (PI) and was sustained through 24 h PI. Decreased expression of immunologically reactive glut-1 and tfR was observed by 2-4 h PI and remained low up to 24 h PI. No induction of VCAM-1, MHC class II molecules or altered constitutive expressio...Continue Reading

References

Jan 1, 1992·Journal of Neurotrauma·H A Kontos, E P Wei
Apr 1, 1992·Archives of Biochemistry and Biophysics·J K BrielandJ C Fantone
Jan 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·P K PanegyresP C Blumbergs
May 15, 1992·Biochemical and Biophysical Research Communications·Y SuzukiT A Raffin
Jul 1, 1992·Trends in Pharmacological Sciences·M C Morganti-KossmannS M Wahl
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·P M Kochanek, J M Hallenbeck
Jul 1, 1992·Journal of Neurochemistry·C M MorrisR G Pullen
Jun 1, 1992·Journal of Applied Physiology·J C LaMannaR M Farrell
Jan 1, 1991·Journal of Neurotrauma·H GoldmanS Murphy
Nov 1, 1991·Journal of Neurochemistry·E M TaylorE H Morgan
Jan 1, 1991·Molecular Aspects of Medicine·P A WardK J Johnson
Feb 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S RehncronaB K Siesjö
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Dore-DuffyR Balabanov
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S JanderG Stoll
Jan 1, 1994·Advances in Neuroimmunology·A A HurwitzW D Lyman
Aug 1, 1993·Cell Biophysics·R M LafrenieF W Orr
Aug 1, 1994·Journal of Applied Physiology·S I HarikJ C LaManna
Feb 1, 1994·Journal of Clinical Pathology·A J WakefieldJ E McLaughlin
Apr 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M E Gerritsen, C M Bloor
Jun 1, 1993·Annals of Emergency Medicine·B K Siesjö
Sep 1, 1996·Journal of Neurotrauma·E M CornfordM J Caron
Mar 2, 1999·Microvascular Research·P Dore-DuffyJ C LaManna

❮ Previous
Next ❯

Citations

Feb 3, 2012·Translational Stroke Research·Adam ChodobskiJoanna Szmydynger-Chodobska
Mar 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Mathew B PottsLinda J Noble-Haeusslein
Jun 17, 2010·Nature Reviews. Neurology·Dan ShlosbergAlon Friedman
Oct 28, 2003·Journal of Neurotrauma·Douglas S DeWitt, Donald S Prough
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Oct 3, 2012·Journal of Neurotrauma·Mayumi L PrinsDavid A Hovda
Feb 7, 2009·Critical Care : the Official Journal of the Critical Care Forum·Monika HolbeinJohn F Stover
Sep 21, 2013·Disease Models & Mechanisms·Mayumi PrinsChristopher C Giza
Dec 11, 2013·Translational Stroke Research·Eric S Hald, Patrick W Alford
Jun 17, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Alfonso Rodríguez-BaezaAngel Garnacho
Apr 13, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Gavin MorrisonGediminas Cepinskas
Jun 7, 2015·Experimental Neurology·Kimbra KenneyRamon Diaz-Arrastia
May 7, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hung-Chen WangCheng-Hsien Lu
Apr 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Arjang SalehiAndre Obenaus
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rossana BertiFrank C Tortella
Aug 23, 2007·Journal of Neurotrauma·Fredrik ClausenLars Hillered
Dec 26, 2013·The Journal of Trauma and Acute Care Surgery·Martin SillesenHasan B Alam
Jan 1, 2017·Journal of Concussion·Ronald SahyouniBrian J Cummings
May 14, 2020·International Journal of Molecular Sciences·Alison Cash, Michelle H Theus
Dec 29, 2020·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Xiao-Jian XuBai-Yun Liu
Oct 15, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cillian E LynchCorbin Bachmeier
Jun 8, 2021·Frontiers in Immunology·Colleen N BodnarAdam D Bachstetter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.