Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome

Critical Care Medicine
M MossPolly E Parsons

Abstract

The endothelial cell produces many bioactive compounds that are presumed to play important roles in the pathogenesis of the adult respiratory distress syndrome (ARDS). We postulated that individuals with sepsis and trauma-two at-risk diagnoses for the development of ARDS--might demonstrate differences in the degree of endothelial cell activity. Prospective cohort study. Intensive care unit patients in a tertiary, university-affiliated, city hospital. Fifty-five intensive care unit patients (19 with sepsis and 36 trauma patients). Plasma measurements of three endothelial cell products--von Willebrand factor antigen, soluble intercellular adhesion molecule-1 (ICAM-1), and soluble E-selectin-were performed within 8 hrs of patients meeting our inclusion criteria, and at the clinical onset of ARDS. Twenty-six percent of the septic patients and 25% of the trauma patients developed ARDS. The median (and 25% to 75% quartiles) concentrations of all three mediators measured in the sepsis patients (von Willebrand factor antigen 399% [375% to 452%], ICAM-1 573 ng/mL [470 to 980], and soluble E-selectin 180 ng/mL [81 to 340]) were significantly higher (p < .001 for each individual analysis) than in the trauma patients (von Willebrand factor...Continue Reading

References

Apr 24, 1976·British Medical Journal·A BartlettA Voller
Mar 1, 1992·Kidney International·R Rothlein, C Wegner
Oct 1, 1992·Current Opinion in Cell Biology·R P McEver
Oct 1, 1992·The Journal of Trauma·O J McAnenaP Pepe
Sep 1, 1985·The Journal of Clinical Investigation·L A SpornD D Wagner
Aug 1, 1989·The American Review of Respiratory Disease·R MoalliT Saldeen
Aug 1, 1986·The Journal of Experimental Medicine·R S CotranJ S Pober
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jan 1, 1985·Annual Review of Public Health·R S Greenberg, D G Kleinbaum
Oct 28, 1982·The New England Journal of Medicine·A C CarvalhoW M Zapol
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Jan 1, 1994·Lung·J Hamacher, T Schaberg
Jun 1, 1993·Critical Care Medicine·R C HochE Abraham
Jun 1, 1996·Clinics in Chest Medicine·P E Parsons, M Moss

❮ Previous
Next ❯

Citations

Jan 20, 2007·Lung·Elizabeth O HarringtonSharon Rounds
Apr 15, 2005·Transfusion Medicine Reviews·Mindy GoldmanUNKNOWN TRALI Consensus Panel
Apr 18, 2000·Critical Care Clinics·A M Fein, M G Calalang-Colucci
May 26, 1999·Infectious Disease Clinics of North America·C Parent, P Q Eichacker
Jan 11, 2000·Critical Care Medicine·B E Van Hoozen, T E Albertson
May 16, 2000·Critical Care Medicine·R L PatersonN R Webster
May 11, 2002·Critical Care Medicine·Konrad ReinhartMichael Meisner
Feb 6, 2004·Critical Care Medicine·Dana E McClintock, Michael A Matthay
Apr 20, 2004·Critical Care Medicine·Stephen Kantrow, Bennett P DeBoisblanc
Jan 13, 2005·Critical Care Medicine·Polly E ParsonsUNKNOWN NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network
Jul 2, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Heidi R FloriMichael A Matthay
Sep 30, 2004·The Journal of Trauma·Rochelle A DickerRobert C Mackersie
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·C J CummingsA A Fowler
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·B JilmaO F Wagner
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·K E Welty-WolfC A Piantadosi
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Lorraine B WareMichael A Matthay
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Mary Y YehLou Ann S Brown
Jan 19, 2013·American Journal of Respiratory and Critical Care Medicine·Ashish AgrawalCarolyn S Calfee
Jun 24, 2005·Respiratory Research·Argyris TzouvelekisDemosthenes Bouros
Jan 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Katharine XingJeffrey M Singh
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Ortrud Vargas HeinClaudia Spies
Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·Hidehiko KushiKatsuhisa Tanjoh
Mar 25, 2008·Critical Care : the Official Journal of the Critical Care Forum·Dana McClintockLorraine B Ware
Oct 21, 2004·Srpski arhiv za celokupno lekarstvo·Dragan J MilićMilan Radojković
Jul 29, 1999·Chest·G A ZimmermanM S Topham
Mar 29, 2011·Critical Care Clinics·L J Mark Cross, Michael A Matthay
Sep 14, 2010·American Journal of Surgery·Lisa M BrownRochelle A Dicker
Dec 7, 2007·Injury·Peter V GiannoudisGeorge Kontakis
Dec 13, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·Kenji OkajimaTakao Nakagawa
Oct 6, 2000·Clinics in Chest Medicine·P E Parsons
Jul 19, 2002·Chest Surgery Clinics of North America·R J Morrison, Akhil Bidani
Jun 18, 2016·Frontiers in Pediatrics·Benjamin E Orwoll, Anil Sapru
May 3, 2013·Angiology·Fabio Silvio TacconeClaudio Napoli
Nov 3, 1998·Public Health Nursing·T M Klein
Oct 10, 2002·Social Work in Health Care·Andrea Rothenberg, Andrew Weissman
Mar 14, 2009·Journal of Intensive Care Medicine·Joseph E LevittMichael A Matthay

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