PMID: 11904623Mar 21, 2002Paper

Endothelial cell apoptosis is induced by fetal plasma from pregnancy with umbilical placental vascular disease

American Journal of Obstetrics and Gynecology
Xin WangBrian Trudinger

Abstract

Vascular disease in the umbilical placental circulation that is detected by umbilical artery Doppler study is associated with adverse fetal outcome. Endothelial cell activation and platelet consumption are features of this pathologic condition. We postulated that this was due to the local release of factors that cause endothelial cell injury and that these would spill into the fetal circulation. To test this hypothesis, we examined for the presence in fetal plasma of factors that induced endothelial cell apoptosis in pregnancies that were complicated by umbilical placental vascular disease. Isolated and cultured human umbilical vein endothelial cells were exposed to fetal plasma from the 3 fetal groups: normal pregnancy (n = 32 patients), pregnancy with umbilical placental vascular disease that was identified by an abnormal umbilical artery Doppler study (n = 38 patients), and pregnancy with maternal preeclampsia and normal umbilical artery Doppler study (n = 16 patients). Early apoptosis can be recognized by a loss of plasma membrane asymmetry with membrane uptake of annexin V. This was measured with annexin V and propidium iodide staining by fluorescent-activated cell scanning. Cells that underwent early apoptosis stained pos...Continue Reading

References

Apr 1, 1991·British Journal of Obstetrics and Gynaecology·B J TrudingerW Wilcox
Jun 1, 1988·British Journal of Obstetrics and Gynaecology·R S ThompsonW B Giles
Jan 1, 1985·British Journal of Obstetrics and Gynaecology·W B GilesP J Baird
Nov 1, 1996·American Journal of Obstetrics and Gynecology·S T DavidgeJ M Roberts
Jan 10, 1998·American Journal of Obstetrics and Gynecology·S C SmithE M Symonds
Sep 29, 1998·Critical Care Medicine·S L DeMeesterJ P Cobb
Apr 12, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·J Wang, B Trudinger
Jul 6, 2000·British Journal of Pharmacology·Z Mallat, A Tedgui
Aug 31, 2000·Gynecologic and Obstetric Investigation·R HalperinD Schneider
Sep 19, 2000·American Journal of Obstetrics and Gynecology·S C SmithP N Baker

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Citations

Nov 25, 2003·American Journal of Obstetrics and Gynecology·Xin WangBrian Trudinger
Mar 9, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shozo MatsuokaTakeshi Maruo
Feb 24, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B Trudinger
Mar 22, 2013·Human & Experimental Toxicology·O G Shaker, N A H Sadik
Jul 24, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Xin WangBrian Trudinger

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