Endothelial cell-cardiomyocyte crosstalk in heart development and disease.

The Journal of Physiology
Andrea CollivaSerena Zacchigna

Abstract

The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for normal cardiac development, but also a key pathogenic player during the onset and progression of cardiac disease. Endothelial cells and cardiomyocytes are in close proximity and communicate through the secretion of paracrine signals, as well as through direct cell-to-cell contact. Here, we provide an overview of the endothelial cell-cardiomyocyte interactions controlling heart development and the main processes affecting the heart in normal and pathological conditions, including ischaemia, remodelling and metabolic dysfunction. We also discuss the possible role of these interactions in cardiac regeneration and encourage the further improvement of in vitro models able to reproduce the complex environment of the cardiac tissue, in order to better define the mechanisms by which endothelial cells and cardiomyocytes interact with a final aim of developing novel therapeutic opportunities.

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Citations

Jul 16, 2020·The Journal of Physiology·Björn C Knollmann
Apr 24, 2020·Frontiers in Cardiovascular Medicine·Verena SchwachRobert Passier
Jun 9, 2020·Frontiers in Endocrinology·Xiaoqiang TangHou-Zao Chen
Nov 27, 2020·Cardiovascular Research·Judy R Sayers, Paul R Riley
Jan 24, 2021·Clinical and Experimental Medicine·R G CarboneF Puppo
Nov 21, 2020·Current Heart Failure Reports·Anton Deicher, Timon Seeger
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Sadek Munawar, Irene C Turnbull
Jun 25, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Ying H Shen, Jun-Ichi Abe
Jun 30, 2021·Cytokine & Growth Factor Reviews·Ni ZhaoLi-Li Xu
Jul 13, 2021·Frontiers in Cardiovascular Medicine·Tiqun YangZhan-Peng Huang
May 9, 2021·Cardiovascular Research·Maggie S ChenJessica C Garbern
Oct 17, 2021·Journal of Cardiovascular Pharmacology·Tianyou WangZhongqun Wang

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