Endothelial cell chimerism associated with graft rejection after human lung transplantation

Transplantation
Hideyuki MurataAnne Janin

Abstract

Endotheliitis is a major sign of graft rejection. Recipient-derived endothelial cells found in two series of liver and kidney transplants were related to graft rejection. Here, we assessed the presence and the number of chimeric endothelial cells in lung transplants, and their relation with graft rejection. In six males grafted with female lungs out of 193 lung transplantations, endothelial chimerism was studied by combined XY-fluorescent in situ hybridization with CD31 and CD45 immunostainings and blood group antigens. On samples graded according to the revised working formulation for lung allograft rejection, we found chimeric macrophages (73.1 to 87.2%) in all cases and chimeric endothelial cells (1.3 to 2.1%) in four patients. Another method using ABO blood group also showed endothelial cells positive for recipient-type blood group antigens in three patients. By both methods, presence of chimeric endothelial cells was related to pathological signs of acute rejection (P<0.05).

References

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Citations

Mar 30, 2012·Transplantation·Tatsu TanabeKazunari Tanabe
Apr 2, 2014·Médecine sciences : M/S·Laurence Verneuil, Anne Janin
Oct 16, 2013·Annals of Plastic Surgery·Pedro Bolado, Luis Landin
Feb 10, 2009·The Journal of Surgical Research·Keiichi MuramatsuToshihiko Taguchi
Jul 10, 2017·Surgery Today·Kyoko HijiyaHiroshi Date

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