Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.

Cell Research
Suyan LiAnju Vasudevan

Abstract

The cerebral cortex is essential for integration and processing of information that is required for most behaviors. The exquisitely precise laminar organization of the cerebral cortex arises during embryonic development when neurons migrate successively from ventricular zones to coalesce into specific cortical layers. While radial glia act as guide rails for projection neuron migration, pre-formed vascular networks provide support and guidance cues for GABAergic interneuron migration. This study provides novel conceptual and mechanistic insights into this paradigm of vascular-neuronal interactions, revealing new mechanisms of GABA and its receptor-mediated signaling via embryonic forebrain endothelial cells. With the use of two new endothelial cell specific conditional mouse models of the GABA pathway (Gabrb3ΔTie2-Cre and VgatΔTie2-Cre), we show that partial or complete loss of GABA release from endothelial cells during embryogenesis results in vascular defects and impairs long-distance migration and positioning of cortical interneurons. The downstream effects of perturbed endothelial cell-derived GABA signaling are critical, leading to lasting changes to cortical circuits and persistent behavioral deficits. Furthermore, we ill...Continue Reading

References

Nov 1, 1979·The Journal of Cell Biology·B HazeltonJ Tupper
May 1, 1972·The Journal of Comparative Neurology·P Rakic
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jun 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M J Berridge
Nov 19, 1993·Brain Research. Developmental Brain Research·N R Kreisman, M L Smith
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M SchlaegerT N Sato
Aug 26, 2000·Brain : a Journal of Neurology·T OhnishiM Sasaki
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y S ChangL L Munn
Mar 3, 2001·Pediatric Research·G L Holmes, Y Ben-Ari
Mar 20, 2001·Critical Reviews in Neurobiology·G SanacoraJ H Krystal
Aug 25, 2001·Epilepsia·D M Treiman
Sep 8, 2001·Cell and Tissue Research·P VarjuG Szabó
Nov 21, 2001·Nature Reviews. Neuroscience·O Marín, J L Rubenstein
Jun 8, 2002·Annual Review of Neuroscience·David A Lewis, Pat Levitt
Sep 7, 2002·Science·Mary E Hatten
Jul 31, 2003·Molecular Psychiatry·P BrambillaJ C Soares
Jun 26, 2004·Science·Anna MolesFrancesca R D'Amato
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Jun 2, 2005·Trends in Neurosciences·Alfonso Represa, Yehezkel Ben-Ari
May 17, 2006·Neuron·Sonja M WojcikJeong-Seop Rhee
Aug 3, 2006·Nature Reviews. Neuroscience·Carl P Wonders, Stewart A Anderson
Apr 5, 2007·Nature Protocols·Robert M J Deacon
May 30, 2007·Brain : a Journal of Neurology·Valérie RigauMireille Lerner-Natoli
Nov 14, 2007·American Journal of Human Genetics·Rainald MoessnerStephen W Scherer
Apr 11, 2008·Cephalalgia : an International Journal of Headache·M BergerA Gorji
Jan 21, 2009·The Journal of Physiology·Doris D Wang, Arnold R Kriegstein
Apr 24, 2009·Cerebral Cortex·Daniel StubbsZoltán Molnár
May 8, 2009·The European Journal of Neuroscience·Mu YangJacqueline N Crawley
Dec 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill L SilvermanJacqueline N Crawley
Jun 2, 2010·Nucleic Acids Research·Dorothea EmigMario Albrecht

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Citations

May 31, 2018·Aging·Yong Kee Choi, Anju Vasudevan
Apr 16, 2019·The Open Neurology Journal·Jugajyoti Baruah, Anju Vasudevan
Oct 9, 2019·Annual Review of Cell and Developmental Biology·Marta SegarraAmparo Acker-Palmer
Jul 15, 2020·Molecular Psychiatry·Debkanya DattaAnju Vasudevan
Mar 21, 2019·Frontiers in Pediatrics·Annalisa M HartlaubMark E Hester
Jul 9, 2020·Nature Reviews. Neuroscience·Luke KaplanChenghua Gu
Feb 11, 2020·Frontiers in Physiology·Jugajyoti BaruahRüdiger Köhling
Oct 11, 2020·Science Advances·Sivan SubburajuAnju Vasudevan
Oct 19, 2020·The Journal of Surgical Research·Mohammadreza TabaryAhmad Reza Dehpour
Mar 8, 2021·Journal of Psychiatric Research·James M ParkSangmi Chung
Jun 3, 2021·Current Opinion in Neurobiology·Blanca PegueraAmparo Acker-Palmer

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Methods Mentioned

BETA
chip
ELISA
dissection
chips
PCR
genotyping

Software Mentioned

ImageJ
GraphPad
AltAnalyze
NeuroLucida
Elite
Neurodigitech
SCAN
CDT
prism
pClamp

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