PMID: 8941535Nov 1, 1996Paper

Endothelial cell dilatory pathways link flow and wall shear stress in an intact arteriolar network

Journal of Applied Physiology
M D Frame, Ingrid H Sarelius

Abstract

Our purpose was to determine whether the endothelial cell-dependent dilatory pathways contribute to the regulation of flow distribution in an intact arteriolar network. Cell flow, wall shear stress (T omega), diameter, and bifurcation angle were determined for four sequential branches of a transverse arteriole in the superfused cremaster muscle of pentobaribtal sodium (Nembutal, 70 mg/kg)-anesthetized hamsters (n = 51). Control cell flow was significantly greater into upstream than into downstream branches [1,561 +/- 315 vs. 971 +/- 200 (SE) cells/s, n = 12]. Tissue exposure to 50 microM N omega-nitro-L-arginine + 50 microM indomethacin (L-NNA + Indo) produced arteriolar constriction of 14 +/- 4% and decreased flow into the transverse arteriole. More of the available cell flow was diverted to downstream branches, yet flow distribution remained unequal. Control T omega was higher upstream than downstream (31.3 +/- 6.8 vs. 9.8 +/- 1.5 dyn/cm2). L-NNA + Indo decreased T omega upstream and increased T omega downstream to become equal in all branches, in contrast to flow. To determine whether constriction in general induced the same changes, 5% O2 (8 +/- 4% constriction) or 10(-9) M norepinephrine (NE; 4 +/- 3% constriction) was add...Continue Reading

References

Oct 1, 1990·Circulation Research·A R PriesJ F Gross
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May 1, 1972·Stroke; a Journal of Cerebral Circulation·M R RoachG G Ferguson
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Jul 1, 1993·Circulation Research·M D Frame, I H Sarelius
Nov 1, 1995·Microvascular Research·M D Frame, I H Sarelius

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Citations

Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·N Thorin-Trescases, J A Bevan
Mar 10, 1999·The American Journal of Physiology·M D Frame
Apr 22, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Olga HudlickaAxel R Pries
Sep 5, 2013·Scientific Reports·Sayan Mullick ChowdhuryBalaji Sitharaman
Apr 30, 1998·Circulation Research·D B CowanB L Langille
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Mary D FrameChen Yan
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·X BaoJ A Frangos
Mar 24, 2007·Journal of Applied Physiology·Mary D FrameScott Cameron
Aug 2, 2002·Anesthesiology·Michael E WardMark R Angle
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M D Frame
Apr 19, 2002·Journal of Applied Physiology·Randall J Fox, Mary D Frame

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