PMID: 9423857Jan 10, 1998Paper

Endothelial cell injury caused by Candida albicans is dependent on iron

Infection and Immunity
R A FrattiScott G Filler

Abstract

Although it is known that Candida albicans causes endothelial cell injury, in vitro and in vivo, the mechanism by which this process occurs remains unknown. Iron is critical for the induction of injury in many types of host cells. Therefore, we investigated the role of iron in Candida-induced endothelial cell injury. We found that pretreatment of endothelial cells with the iron chelators phenanthroline and deferoxamine protected them from candidal injury, even though the organisms germinated and grew normally. Loading endothelial cells with iron reversed the cytoprotective effects of iron chelation. Moreover, chelation of endothelial cell iron significantly reduced phagocytosis of C. albicans by these cells, while candidal adherence to chelator-treated endothelial cells was slightly enhanced. Since endothelial cell phagocytosis of C. albicans is required for endothelial cell injury to occur, inhibition of phagocytosis is likely the principal mechanism of the cytoprotective effects of iron chelation. The production of toxic reactive oxygen intermediates by host cells is known to be inhibited by iron chelation. Therefore, we investigated whether treating endothelial cells with antioxidants could mimic the cytoprotective effects o...Continue Reading

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Citations

May 19, 2000·Infection and Immunity·Q T PhanS G Filler
Jun 13, 2001·Infection and Immunity·A Y JongK S Kim
Nov 18, 2005·Journal of Dairy Science·K LauzonP Lacasse
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