Endothelial cell monolayers as a tool for studying microvascular pathophysiology

The American Journal of Physiology
P R Kvietys, D N Granger

Abstract

Endothelial cells contribute to a variety of biological responses that facilitate organ function. This critical role of the endothelial cell has resulted in the development of different in vitro models that utilize monolayers of cultured cells to simulate conditions that exist in the intact animal. This review focuses on endothelial cell monolayers as a model system for research on certain pathophysiological conditions affecting the gastrointestinal tract. The advantages and limitations of endothelial cell monolayers are addressed, along with evolving technologies and strategies that hold promise for extending the utility of this in vitro model for studies of gastrointestinal function and disease.

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Citations

Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T RuiP R Kvietys
Oct 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ossama A HatoumDavid G Binion
Sep 11, 2007·Archives of Histology and Cytology·Fan-Wei MengSeiji Kato
Sep 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Gregory P VictorinoJavid Sadjadi
May 15, 2013·Bioprocess and Biosystems Engineering·Jong Seob ChoiTae Seok Seo
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·P R Kvietys, M Sandig
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sakuji ShigematsuRonald J Korthuis
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J RussellD N Granger
Oct 7, 2020·International Journal of Molecular Sciences·Miriam AyusoChris Van Ginneken

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