Endothelial cell proliferation in the choriocapillaris during human retinal differentiation.

The British Journal of Ophthalmology
A AllendeJ Provis

Abstract

Differentiation patterns of the neural retina and its retinal vasculature are not well matched. The foveal region differentiates first, however the central retina is not vascularised until late in gestation. The authors explored the hypothesis that higher rates of endothelial cell proliferation in the choriocapillaris of the central retina might compensate for the slow growth of central retinal vessels, providing supplementary nutrients to the region during the early stages of neuronal maturation. Frozen sections of five human fetal eyes (14-18.5 weeks' gestation), were examined for Ki-67 and CD34 immunoreactivity using confocal microscopy. Measurements of choriocapillaris area and the number of proliferating choroidal endothelial cells were used to calculate the rate of choroidal endothelial proliferation at five different chorioretinal locations. The choriocapillaris area is consistently greater in the foveal region than at other locations and increases progressively with age. A higher rate of endothelial cell proliferation was found in parts of the choriocapillaris associated with the undifferentiated (proliferating) neural retina, compared with the differentiated, central region. The findings suggest that mechanisms regulat...Continue Reading

References

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Citations

Dec 9, 2014·Progress in Retinal and Eye Research·S Scott WhitmoreRobert F Mullins
Aug 20, 2014·Experimental Eye Research·Martina C HerwigAnnette M Müller
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani

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