Abstract
Endothelial cell protein C receptor (EPCR) enhances the generation of activated protein C by the thrombin-thrombomodulin complex. A soluble form of EPCR (sEPCR) is present in plasma. Two polymorphisms in the EPCR gene (6936A/G and 4678G/C) have been reported to influence the risk of venous thromboembolism. We aimed to investigate the relation between EPCR gene polymorphisms (6936A/G and 4678C/G) and deep venous thrombosis (DVT) and their relations to sEPCR level. This study involved 90 patients with DVT and 90 age and sex-matched healthy controls. Plasma levels of sEPCR were measured in 45 cases of the primary DVT by ELISA. PCR-restriction fragment length polymorphism (RFLP) was used for detection of EPCR polymorphisms (6936A/G and 4678G/C). Regarding 6936A/G, our results demonstrated that mutant genotypes (AG, GG) were associated with an increased risk for DVT [P < 0.001, odds ratio (OR) 4.125, 95% confidence interval (95% CI) 2.198-7.740] as well as its mutant allele G (P < 0.001, OR 2.549, 95% CI 1.601-4.061). The mutant genotypes were associated with increased levels of sEPCR. Although in 4678G/C, our results demonstrated that the mutant genotype (CC) was considered as a protective factor against DVT (P = 0.014, OR 0.289, 9...Continue Reading
References
Dec 15, 1996·Annals of Internal Medicine·P W FriederichM H Prins
Apr 21, 1999·Lancet·F R Rosendaal
Nov 11, 1999·Protein Engineering·B O VilloutreixB Dahlbäck
Nov 10, 2001·Human Genetics·R F Franco, P H Reitsma
Jan 10, 2002·Blood·Deborah J Stearns-KurosawaShinichiro Kurosawa
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J S Ginsberg, S M Bates
Oct 25, 2003·Blood·Beatrice SaposnikSophie Gandrille
Apr 30, 2004·Thrombosis and Haemostasis·Pilar MedinaFrancisco España
Jul 28, 2004·British Journal of Anaesthesia·A M Mahdy, N R Webster
Aug 12, 2004·Journal of Thrombosis and Haemostasis : JTH·S Uitte de WilligeR M Bertina
Jun 16, 2005·Kidney International·Carlos A SesinRobert M Clancy
Jul 21, 2006·Pathophysiology of Haemostasis and Thrombosis·Paolo Prandoni
Nov 21, 2007·Hematology·John A Heit
Dec 13, 2007·Blood·Beatrice SaposnikSophie Gandrille
Jun 3, 2008·Haematologica·Sophie Gandrille
Aug 30, 2008·The New England Journal of Medicine·Bruce Furie, Barbara C Furie
Jul 17, 2009·Genetic Testing and Molecular Biomarkers·Carolina I PestanaAntonietta Porco
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·F R Rosendaal, P H Reitsma
Sep 13, 2012·Experimental and Therapeutic Medicine·Guancheng YinDeqing Zhang
Jan 18, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·P MedinaF España
Citations
Jan 1, 2014·Human Immunology·Bo TangJian-Ming Sun
Mar 30, 2017·Medicine·Jun JiangYuanyong Jiao
Jun 22, 2018·Hematology·Jiasheng Xu, Weimin Zhou
Jun 13, 2017·Frontiers in Physiology·Yan-Yan LiHyun Jun Kim
Apr 19, 2017·The Journal of International Medical Research·Yanbing LiangLiao Pinhu