Endothelial cells in health and disease

Antioxidants & Redox Signaling
Anna Eckers, Judith Haendeler

Abstract

According to the World Health Organization, from 2014, cardiovascular diseases (CVD) are the number one cause of death worldwide. One of the key players in maintaining proper cardiovascular function is the endothelium, the inner layer of all blood vessels. This monolayer of cells on one hand serves as a barrier between blood and the surrounding tissue and on the other hand regulates many aspects of vessel function. Therefore, it is not surprising that interventions reducing the risk for CVD improve endothelial function. There is a clear correlation between endothelial dysfunction, in which the endothelial homeostasis is disturbed, and the development and progression of many CVD. Thus, the development of diagnostic tools for early detection of disturbances in endothelial homeostasis or interventions aimed at improving endothelial function after insults require a comprehensive knowledge not only of the cellular reactions to the positive or negative stimuli but also of the molecular mechanisms relaying these responses. Thus, this Forum on "endothelial cells in health and disease" focuses on key molecules and processes intimately involved in endothelial cell function and covers areas from endothelial nitric oxide synthase-dependent...Continue Reading

References

Aug 7, 2002·Circulation·Joseph A Vita, John F Keaney
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Sep 10, 2014·Antioxidants & Redox Signaling·Sabrina FarrokhHeiner Schaal
Oct 21, 2014·Antioxidants & Redox Signaling·Christian HeissMalte Kelm
Feb 18, 2015·Antioxidants & Redox Signaling·Ryan M Burke, Bradford C Berk
Mar 13, 2015·Antioxidants & Redox Signaling·Mithun SinhaChandan K Sen

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Citations

Jan 2, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A O LawalJ L Marnewick
Jan 18, 2017·BioMed Research International·Xiao LinYou-Shuo Liu
Nov 10, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shuangshuang DuChunli Song

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