PMID: 15348707Sep 7, 2004Paper

Endothelial cells on plasma-treated segmented-polyurethane: adhesion strength, antithrombogenicity and cultivation in tubes

Journal of Materials Science. Materials in Medicine
Y KawamotoM Kaibara

Abstract

When the surface of segmented-polyurethane (SPU), where endothelial cells are not capable of proliferating, is modified by plasma treatment, the adhesion and proliferation of bovine aortic endothelial cells (BAECs) can be drastically improved. The cells were capable of proliferating on the inner surface of a plasma-treated SPU-coated tube (length: 50 mm; inner diameter: 1.5 mm). When a steady flow shear stress of 9 Pa was applied to the cells proliferated on the modified SPU surface for 90 min, most cells did not detach from the surface. From an in vitro evaluation test of antithrombogenicity, the cell surface can be considered to provide an inert surface against thrombus formation and blood coagulation. From analyses of the plasma-treated SPU surface, it was suggested that the improvements in BAEC proliferation and adhesion after plasma treatment were due to the change in wettability of the surface. Data suggest that the plasma treatment would be useful for developing a small-calibre hybrid vascular graft.

Citations

Jan 30, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Junko HiedaTakao Hanawa
Sep 1, 2005·Journal of Biomaterials Science. Polymer Edition·S DeJ L Mehta
Jun 27, 2009·Journal of Biomedical Materials Research. Part a·Nurdan OzkucurT K Monsees
Jun 5, 2014·BioMed Research International·Saravana Kumar JaganathanManjeesh Kumar Asokan
Jul 27, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·B N BlackstoneH M Powell
Apr 3, 2013·Journal of Biomaterials Science. Polymer Edition·J L A Perales-AlcacioJ V Cauich-Rodríguez
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Naian ShenJin-Ye Wang
Sep 1, 2000·Colloids and Surfaces. B, Biointerfaces·H IwataH Nakajima

❮ Previous
Next ❯

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.