Endothelial damage effects of circulating microparticles from patients with stable angina are reduced by aspirin through ERK/p38 MAPKs pathways

Cardiovascular Therapeutics
Gong ChengFeng-Jun Chang

Abstract

Platelet activation participates in the development of both coronary artery disease (CAD) and circulating microparticles (MPs). As a commonly used medicine for coronary heart disease, whether aspirin affects the function of MPs remains unclear. This study was designed to test MPs from healthy subjects, and stable angina (SA) patients before and after aspirin administration were obtained. MPs origins were tested by flow cytometry. Rat thoracic aortas were incubated with MPs (with or without aspirin) to determine the effects of MPs on expression of ERK1/2, JNKs, and p38 MAPK. Affect on levels of NF-κB, VCAM-1, NO, and O2-. Compared with healthy subjects, MPs concentrations increased in SA patients, but decreased after aspirin administration. According to flow cytometry, aspirin mainly decreased platelet-derived MP. MPs from SA patients decreased the expression of ERK1/2, increased expression of p38 MAPKs, JNKs. Increased NF-κB, VCAM-1, and (O2-) levels decreased NO content. Aspirin therapy significantly inhibited function of MPs from SA patients, and pathway inhibitors (ERK1/2 inhibitor PD98059, p38 MAPKs inhibitor SB203580, NF-kB inhibitor PDTC) show similar effects with aspirin. These results indicate that the pro-inflammatory,...Continue Reading

References

Nov 24, 1995·Science·Z XiaM E Greenberg
Sep 20, 1997·The American Journal of Cardiology·S D KristensenE Falk
Apr 21, 1999·Current Opinion in Cell Biology·T P Garrington, G L Johnson
May 18, 2000·Brain Research. Molecular Brain Research·E A IrvingA A Parsons
Feb 22, 2002·Medicinal Research Reviews·Helena Yusuf-MakagiansarTeruna J Siahaan
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J E Freedman, J Loscalzo
Aug 12, 2003·Cardiovascular Research·Marja J VanWijkR Nieuwland
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·M Carmen MartínezRamaroson Andriantsitohaina
Jun 2, 2009·The Journal of Surgical Research·Yi Xin WangCan Ping Ruan
Apr 14, 2010·The Canadian Journal of Cardiology·Paolo PudduAntonio Muscari
Aug 3, 2010·Clinical Hemorheology and Microcirculation·Andrew LiuniJohn D Parker
Jan 5, 2011·Cell Metabolism·Rebecca G BakerSankar Ghosh
Mar 1, 2012·Thrombosis and Haemostasis·Mika SkeppholmHåkan Wallén
Apr 27, 2012·Physiological Reviews·John M Kyriakis, Joseph Avruch
Jun 6, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Luigi Marzio BiasucciFilippo Crea
Jul 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Mohammed Ahmed Saad AlmansobJing-Song Ou
Feb 7, 2013·American Journal of Physiology. Endocrinology and Metabolism·Hong-Bo CiJing-Song Ou
Apr 30, 2016·The Journal of Biological Chemistry·Christine HinzValerie B O'Donnell
Aug 23, 2016·Texas Heart Institute Journal·Robert W Godley, Eduardo Hernandez-Vila

❮ Previous
Next ❯

Citations

Sep 29, 2019·Journal of Cellular and Molecular Medicine·YingMei LvQiang Zhang
Nov 30, 2019·Frontiers in Pharmacology·Francesco TausPietro Minuz
Feb 13, 2021·Platelets·Pamela CzajkaCeren Eyileten
Jul 27, 2021·Frontiers in Immunology·Esha SehanobishElina Jerschow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.