Endothelial-derived plasma exosome proteins in Alzheimer's disease angiopathy.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Erin L AbnerE. J. Goetzl

Abstract

Small cerebral vascular disease (SCeVD) demonstrated by white matter hyperintensity (WMH) on MRI contributes to the development of dementia in Alzheimer's disease (AD), but it has not been possible to correlate onset, severity, or protein components of SCeVD with characteristics of WMH in living patients. Plasma endothelial-derived exosomes (EDEs) were enriched by two-step immunoabsorption from four groups of participants with no clinical evidence of cerebrovascular disease: cognitively normal (CN) without WMH (CN without SCeVD, n = 20), CN with SCeVD (n = 22), preclinical AD (pAD) + mild cognitive impairment (MCI) without SCeVD (pAD/MCI without SCeVD, n = 22), and pAD/MCI with SCeVD (n = 16) for ELISA quantification of cargo proteins. Exosome marker CD81-normalized EDE levels of the cerebrovascular-selective biomarkers large neutral amino acid transporter 1 (LAT-1), glucose transporter type 1 (Glut-1), and permeability-glycoprotein (p-GP, ABCB1) were similarly significantly higher in the CN with SCeVD and pAD/MCI with SCeVD groups than their corresponding control groups without SCeVD. CD81-normalized EDE levels of Aβ40 and Aβ42 were significantly higher in the pAD/MCI with SCeVD group but not in the CN with SCeVD group relativ...Continue Reading

References

Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·R J BoadoW M Pardridge
Jun 6, 2000·Advanced Drug Delivery Reviews·A H Schinkel
Mar 20, 2002·Cerebrovascular Diseases·Raj N Kalaria
Sep 11, 2003·Annals of Internal Medicine·David A Snowdon, UNKNOWN Nun Study
Dec 11, 2003·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Joel H KramerBruce L Miller
Sep 18, 2004·Stroke; a Journal of Cerebral Circulation·Alex E RoherThomas G Beach
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 12, 2010·Journal of Alzheimer's Disease : JAD·Isobel J WhitehouseNigel M Hooper
Jan 20, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J De ReuckF Pasquier
Aug 19, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Massimo S FiandacaEdward J Goetzl
Aug 15, 2015·Annals of Clinical and Translational Neurology·Edward J GoetzlDimitrios Kapogiannis
Dec 30, 2015·Acta Neuropathologica·Seth Love, J Scott Miners
Jan 21, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Roxane PeresEric Jouvent
Feb 18, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gordon W BlairJoanna M Wardlaw
Feb 26, 2016·Annals of Neurology·Matthew TraylorUNKNOWN International Genomics of Alzheimer's Project (IGAP), investigators
Jun 22, 2016·Nature Communications·Y Iturria-MedinaUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 1, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sean M NestorSandra E Black
Apr 22, 2017·Frontiers in Molecular Biosciences·Andrew R Castle, Andrew C Gill
May 4, 2017·BMC Biology·Marie-Angela WulfAdriano Aguzzi
May 10, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Edward J GoetzlGregory A Jicha
Nov 8, 2018·Journal of Alzheimer's Disease : JAD·Omar M Al-JanabiGregory A Jicha
Nov 30, 2018·Frontiers in Aging Neuroscience·Fanny M ElahiJoel H Kramer
Jan 4, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Edward J GoetzlAurélie Ledreux
Jan 22, 2019·Stroke; a Journal of Cerebral Circulation·Whitney M FreezeSusanne J van Veluw
Feb 28, 2019·Acta Neuropathologica Communications·Yingjian YouCristian A Lasagna-Reeves
Apr 12, 2019·Frontiers in Neurology·Benedikt M FreyGötz Thomalla
Jul 31, 2019·Annals of Neurology·Juliane SchelleMathias Jucker
Aug 24, 2019·Journal of Neurotrauma·Edward J GoetzlKristine Yaffe
Dec 13, 2019·Nature Reviews. Neurology·Steven M GreenbergSusanne J van Veluw

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Citations

Aug 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Edward J Goetzl
Aug 30, 2020·Cells·Sherin SaheeraPrasanna Krishnamurthy
Oct 20, 2020·Frontiers in Oncology·Tao FanJie He
Mar 22, 2021·Molecular Neurobiology·Nashmin FayaziRezvan Najafi
Jun 1, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Claire E SextonMaria C Carrillo

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