Endothelial derived relaxing factor controls renal hemodynamics in the normal rat kidney.

Journal of the American Society of Nephrology : JASN
C BaylisK Engels

Abstract

These studies were conducted in the conscious, chronically catheterized rat to determine whether the endothelial derived relaxing factor (EDRF) controls renal function in the normal state. Administration of the EDRF synthesis inhibitors N-monomethyl-L-arginine (NMA; 100 mg/kg body weight) or N-nitro-L-arginine methylester (NAME; 10 mg/kg body wt) led to a large, sustained rise in blood pressure, a large rise in renal vascular resistance, a fall in renal plasma flow, a relatively slight reduction in glomerular filtration rate, and a consequent rise in filtration fraction. In addition, a marked natriuresis occurred because of a reduction in the fractional reabsorption of sodium. In separate studies, a continuous infusion of excess L-arginine (300 mg/kg body wt bolus followed by 50 mg/kg body wt per min) attenuated the NMA- or NAME-induced rise in blood pressure and reversed the renal hemodynamic effects such that a significant rise in renal plasma flow was seen. L-Arginine alone produced a selective renal vasodilation and large increases in sodium excretion. These observations support earlier suggestions that tonic release of EDRF controls the basal blood pressure and also show that renal function in the normal unstressed rat is ...Continue Reading

Citations

Apr 29, 2000·Current Opinion in Urology·D DemetriouB Watschinger
May 10, 2000·Clinical and Experimental Hypertension : CHE·U VenkatakrishnanM F Lokhandwala
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S Erkasap, E Ates
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M M RahmanJ F Moorhead
Jul 8, 1999·European Journal of Pharmacology·M TanahashiS Satoh
Jun 6, 1997·Environmental Toxicology and Pharmacology·J M ValdivielsoJ M López-Novoa
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·M FrancoJ Herrera-Acosta
Feb 26, 2000·Acta Physiologica Scandinavica·R C BlantzC Kelly
Feb 26, 2000·Acta Physiologica Scandinavica·J P Granger, B T Alexander
Oct 21, 2000·American Journal of Hypertension·C Qiu, C Baylis
Feb 15, 2001·The Journal of Laboratory and Clinical Medicine·D SchwartzR C Blantz
May 25, 2001·Journal of the American Society of Nephrology : JASN·Andreas PatzakPontus B Persson
Jun 26, 2001·Clinical and Experimental Pharmacology & Physiology·M A CostaC T Arranz
Jul 5, 2001·Mechanisms of Ageing and Development·Z GreenfeldC Baylis
Dec 1, 2001·Clinical and Experimental Hypertension : CHE·M A BayorhM Thierry-Palmer
Aug 8, 2002·Clinical and Experimental Pharmacology & Physiology·Maria de los Angeles CostaC T Arranz
Dec 1, 1992·Journal of Pharmacological and Toxicological Methods·P C Raich, B G Zimmerman
Oct 31, 1998·Journal of Hypertension·A Sánchez-MendozaB Escalante
Apr 16, 1998·Journal of Hypertension·C WenJ A Whitworth
Aug 29, 2002·Journal of Cardiovascular Pharmacology·Yolanda MartinezBruno Escalante
Jun 27, 2003·Journal of Cardiovascular Pharmacology·Shuang-Shuang DingMartine Clozel
Sep 15, 1998·Kidney International. Supplement·C MullerJ J Helwig
Jul 1, 1995·The Journal of Trauma·R N GarrisonD A Spain
Aug 28, 2003·Acta Physiologica Scandinavica·J PittnerA E G Persson
Jun 1, 1997·The Journal of Laboratory and Clinical Medicine·Z AbassiA I Alayash
Jul 17, 1998·The Journal of Laboratory and Clinical Medicine·B MathesonE Bucci
Jul 15, 2004·Seminars in Nephrology·Joseph MattanaPravin C Singhal
Jul 15, 2004·Seminars in Nephrology·Saulo Klahr, Jeremiah Morrissey
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Joan C KrepinskyJames W Scholey
Jun 1, 1995·Pflügers Archiv : European journal of physiology·J WagnerE Ritz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.