Aging is an important risk factor for the development of many cardiovascular diseases as atherosclerosis and hypertension with a common underlying circumstance: the progressive decline of endothelial function. Vascular endothelial dysfunction occurs during the human aging process and is accompanied by deterioration in the balance between vasodilator and vasoconstriction substances produced by the endothelium. This imbalance is mainly characterized by a progressive reduction of the bioavailability of nitric oxide (NO) and an increase in the production of cyclooxygenase (COX)-derived vasoconstrictor factors. Both circumstances are in turn related to an increased production of reactive oxygen and nitrogen species. The aim of this review is to describe the pathophysiological mechanisms involved in the endothelial function declination that accompanies the multifactorial aging process, including alterations related to oxidative stress and pro-inflammatory cytokines, senescence of endothelial cells and genetic factors.
Roles of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation
Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats
Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging
Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
Increased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: implications for atherosclerosis
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin
Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism
Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease
The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.
Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery
Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells
Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles
Western-style diet modulates contractile responses to phenylephrine differently in mesenteric arteries from senescence-accelerated prone (SAMP8) and resistant (SAMR1) mice
Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people
How to utilize Ca²⁺ signals to rejuvenate the repairative phenotype of senescent endothelial progenitor cells in elderly patients affected by cardiovascular diseases: a useful therapeutic support of surgical approach?
Attenuation of L-type Ca²⁺ channel expression and vasomotor response in the aorta with age in both Wistar-Kyoto and spontaneously hypertensive rats
Endothelial cell apoptosis in brown adipose tissue of rats induced by hyperinsulinaemia: the possible role of TNF-α
Selected activities of Citrus maxima Merr. fruits on human endothelial cells: enhancing cell migration and delaying cellular aging
Exposure to high or low glucose levels accelerates the appearance of markers of endothelial cell senescence and induces dysregulation of nitric oxide synthase
Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome
The asymmetric dimethylarginine level is associated with the predicted stroke risk in Japanese women
Biochemical and molecular aspects of vascular adrenergic regulation of blood pressure in the elderly
Low-dose irradiation causes rapid alterations to the proteome of the human endothelial cell line EA.hy926
Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction
Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice
Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women
Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture
Statin use and incident erectile dysfunction--A nationwide propensity-matched cohort study in Taiwan
Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation
Knockdown of paraoxonase 1 expression influences the ageing of human dermal microvascular endothelial cells
Decreased expression of heme oxygenase is associated with depressive symptoms and may contribute to depressive and hypertensive comorbidity
Chronic bladder ischemia and oxidative stress: new pharmacotherapeutic targets for lower urinary tract symptoms
Western-type diet induces senescence, modifies vascular function in non-senescence mice and triggers adaptive mechanisms in senescent ones
The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress
Chronic Gamma-Irradiation Induces a Dose-Rate-Dependent Pro-inflammatory Response and Associated Loss of Function in Human Umbilical Vein Endothelial Cells
Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta
Western diet consumption promotes vascular remodeling in non-senescent mice consistent with accelerated senescence, but does not modify vascular morphology in senescent ones
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