Endothelial dysfunction and diabetes

Medicinski pregled
Edita StokićDorde Radak

Abstract

ENDOTHELIAL FUNCTION AND DYSFUNCTION: During the past two decades, there has been an increasing recognition of the importance of normal endothelial function in the maintenance of vascular homeostasis and vascular health. Abnormalities in the function of endothelium have been recognized in a number of conditions. One of the most important abnormalities of endothelial dysfunction appears to be changes in the bioavailability of nitric oxide. It now appears clear that abnormalities in endothelial dysfunction are associated with abnormalities in the production of nitric oxide and/or abnormalities in the rate of its degragation. Either way, loss of the functional availability of nitric oxide appears to be an important characteristic of endothelial dysfunction. ENDOTHELIAL DYSFUNCTION AND DIABETES: Impaired endothelial-dependent vasodilatation has been described in patients with type 1 and type 2 diabetes, and the degree of impairment may correlate with glycemic control. Hyperglycemia itself appears to affect multiple mechanisms that increase atherosclerosis. Hyperglycemia enhances oxidation, thrombosis, inflammation, matrix production, and the formation of advanced glycation end-products and other metabolites that can potentially dam...Continue Reading

References

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Citations

Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael Mendoza, Zobair Younossi
Nov 15, 2017·Cardiovascular Endocrinology·William M SchultzLaurence S Sperling

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