Endothelial dysfunction and history of recurrent depression in postmenopausal women with Type 2 diabetes: a case-control study

Journal of Diabetes and Its Complications
Julie A WagnerGina Abbott

Abstract

This study of postmenopausal women with Type 2 diabetes mellitus (T2DM) investigated (1) history of depression as a predictor of endothelium-dependent flow-mediated dilation (FMD); (2) the relative associations of single and recurrent depressive disorders with FMD; and (3) cortisol as a potential mechanism. Participants were nonsmoking, naturally postmenopausal women with T2DM with no known vascular disease. All were free of current mood disorder. On average, the 44 participants were 63 years of age, White, diabetic for 6 years, and were in adequate glycemic control. Thirty-eight percent were never depressed, 19% had experienced one disorder, and 43% had experienced recurrent disorders. History of depression was assessed with Structured Clinical Interview for Diagnostic and Statistical Manual-IV. Current depressive symptoms were measured with Center for Epidemiological Studies Depression (CESD) scale. FMD was assessed by standard procedures and calculated as percent change in brachial artery diameter from baseline. Women with history of recurrent depression showed vasoconstriction (mean=-1%), which was significantly different from women with history of single depression (mean=+6) and never depressed women (mean=+5) (P<.05), bot...Continue Reading

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Citations

Oct 4, 2011·International Journal of Behavioral Medicine·Julie A WagnerNimrta Ghuman
May 1, 2009·Diabetes/metabolism Research and Reviews
Feb 22, 2011·Biological Psychiatry·Adrie SeldenrijkBrenda W J H Penninx
Aug 10, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·T RoyN Sartorius
Jun 16, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·J A WagnerC Y Osborn
Jun 30, 2015·Journal of Women's Health·Syed Shahzad HasanTherese Kairuz
Jun 24, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hui ShiGang Wang
Dec 4, 2014·Journal of Cardiovascular Pharmacology·Elena V BouzinovaVladimir V Matchkov
Jul 23, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Abdullah AkpinarSuleyman Onal
Jun 1, 2013·Journal of Affective Disorders·Michael Windle, Rebecca C Windle
Feb 7, 2015·Medical Hypotheses·Puneetpal SinghSarabjit Mastana
May 4, 2011·Psychosomatic Medicine·Ronald G GarcíaPatricio López-Jaramillo
Jun 4, 2011·Psychosomatic Medicine·Denise C CooperJoel E Dimsdale
Jun 10, 2017·Acta Cardiologica·Abdulselam IlterEyyup Tusun
Mar 15, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marta Andrea SiragusaThomas Desmidt

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