Endothelial Dysfunction and Inflammation Precedes Elevations in Blood Pressure Induced by a High-Fat Diet

Arquivos brasileiros de cardiologia
Jorge Camargo OishiGerson Jhonatan Rodrigues

Abstract

Obesity leads to a chronic inflammatory state, endothelial dysfunction and hypertension. To establish the time-course of events regarding inflammatory markers, endothelial dysfunction, systolic blood pressure (SBP) in obesity in only one experimental model. We fed male Wistar rats (eight-week age) with a standard diet (Control - CT, n = 35), or palatable high-fat diet (HFD, n = 35) for 24 weeks. Every six weeks, 7 animals from each group were randomly selected for euthanasia. SBP and serum levels of interleukin-6, tumor necrosis factor-α, C-reactive protein, adiponectin and nitric oxide were determined. Endothelial and vascular smooth muscle functions were determined in dissected aorta and lipid peroxidation was measured. Statistical significance was set at p < 0.05. Levels of pro-inflammatory cytokines began to increase after six weeks of a high-fat diet, while those of the anti-inflammatory cytokine adiponectin decreased. Interestingly, the endothelial function and serum nitric oxide began to decrease after six weeks in HFD group. The SBP and lipid peroxidation began to increase at 12 weeks in HFD group. In addition, we showed that total visceral fat mass was negatively correlated with endothelial function and positively corr...Continue Reading

Citations

Jun 28, 2019·Canadian Journal of Physiology and Pharmacology·Conrad MoganeFrederic S Michel
Dec 15, 2020·Journal of Medical Biochemistry·Emre AvciCumhur Bilgi
Mar 19, 2021·Lasers in Medical Science·Luis Henrique Oliveira de MoraesGerson Jhonatan Rodrigues
Mar 16, 2021·Frontiers in Physiology·Leandro Ribeiro CostaAna Cláudia Garcia de Oliveira Duarte
Apr 4, 2021·Antioxidants·Ernesto Martínez-MartínezVictoria Cachofeiro
May 1, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie W WattsGregory D Fink

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
dissection
X-ray

Software Mentioned

StatSoft
GraphPad Prism
ImageJ
Statistica

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