Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches

Journal of Korean Medical Science
Kyoung-Ha Park, Woo Jung Park

Abstract

Atherosclerosis is a chronic progressive vascular disease. It starts early in life, has a long asymptomatic phase, and a progression accelerated by various cardiovascular risk factors. The endothelium is an active inner layer of the blood vessel. It generates many factors that regulate vascular tone, the adhesion of circulating blood cells, smooth muscle proliferation, and inflammation, which are the key mechanisms of atherosclerosis and can contribute to the development of cardiovascular events. There is growing evidence that functional impairment of the endothelium is one of the first recognizable signs of development of atherosclerosis and is present long before the occurrence of atherosclerotic cardiovascular disease. Therefore, understanding the endothelium's central role provides not only insights into pathophysiology, but also a possible clinical opportunity to detect early disease, stratify cardiovascular risk, and assess response to treatments. In the present review, we will discuss the clinical implications of endothelial function as well as the therapeutic issues for endothelial dysfunction in cardiovascular disease as primary and secondary endothelial therapy.

Associated Clinical Trials

References

Feb 23, 1995·The New England Journal of Medicine·T J AndersonP Ganz
Jan 1, 1994·Pharmacology & Therapeutics·J M WoodJ Maibaum
Jan 18, 1996·The New England Journal of Medicine·D S CelermajerJ E Deanfield
Aug 1, 1996·Circulation·S Rajagopalan, D G Harrison
Jan 14, 1999·The New England Journal of Medicine·R Ross
May 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·S M HollenbergL W Klein
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S E EpsteinD Hajjar
Jun 24, 2000·Annals of the New York Academy of Sciences·M A GimbroneG Garcia-Cardeña
Sep 9, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·M TorzewskiJ Torzewski
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·K BoveA Johnson
Aug 17, 2001·Current Opinion in Lipidology·S KinlayP Ganz
Oct 27, 2001·Circulation Research·G J Blake, P M Ridker
Jan 29, 2002·Journal of Cardiovascular Pharmacology·M Barton, C C Haudenschild
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Jul 10, 2002·Circulation·Abhiram PrasadArshed A Quyyumi
Jul 27, 2002·Journal of the American College of Cardiology·Maria G ModenaRosario Rossi
Oct 4, 2002·Current Atherosclerosis Reports·Paul Poirier, Robert H Eckel
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Piero O BonettiAmir Lerman
Feb 20, 2003·European Heart Journal·P O BonettiA Lerman
Aug 16, 2003·Progress in Cardiovascular Diseases·Anne Burke, Garret A Fitzgerald
Sep 19, 2003·Pathophysiology of Haemostasis and Thrombosis·P Poredos
Dec 6, 2003·Hypertension·Carmine CardilloJulio A Panza
Dec 11, 2003·Atherosclerosis. Supplements·Rainer H BögerJohn P Cooke
Feb 21, 2004·Free Radical Biology & Medicine·Tienush RassafMalte Kelm
Mar 12, 2004·The Journal of Surgical Research·R G CaseyD J Bouchier-Hayes
Jul 6, 2004·The American Journal of Medicine·Willa A HsuehManuel J Quiñones
Aug 24, 2004·Current Vascular Pharmacology·Tobias TraupeMatthias Barton

❮ Previous
Next ❯

Citations

Jan 19, 2016·Experimental and Molecular Pathology·Dimitry A ChistiakovYuri V Bobryshev
Apr 28, 2016·Archivos de cardiología de México·Iván Rodríguez-NúñezMaría Javiera Saavedra
May 6, 2016·Lasers in Medical Science·Ana Tereza Barufi FrancoStella Regina Zamuner
Jun 4, 2016·Vascular Pharmacology·Natalia Di PietroAssunta Pandolfi
Jul 13, 2016·Mediators of Inflammation·Mei-Hua BaoHong-Hao Zhou
Jul 1, 2016·Expert Review of Cardiovascular Therapy·Hanna A Jensen, Jawahar L Mehta
Jul 22, 2016·The Journal of Clinical Hypertension·Zengchun YeTanqi Lou
Aug 16, 2016·The Science of the Total Environment·Lucía G Pruneda-AlvarezIván N Pérez-Maldonado
Aug 26, 2016·Molecular Nutrition & Food Research·Brett Ronald CutlerPon Velayutham Anandh Babu
Nov 1, 2016·Environmental Science and Pollution Research International·Ángeles C Ochoa-MartínezIván N Pérez-Maldonado
Dec 8, 2016·Journal of Neurochemistry·Marta Machado-PereiraRaquel Ferreira
Jun 21, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Bandana ShresthaChristopher B Pattillo
Aug 22, 2018·Food & Function·Israel Ramirez-SanchezFrancisco J Villarreal
Nov 14, 2018·VASA. Zeitschrift für Gefässkrankheiten·Richard ShemiltFaisel Khan
Mar 23, 2019·International Journal of Molecular Sciences·Daniela LiccardoGiuseppe Rengo
Oct 28, 2019·Journal of Cardiovascular Pharmacology·Wei Chih LingDharmani Devi Murugan
Feb 25, 2020·The Journal of Clinical Hypertension·Selcuk CandanTurgut Karabag
Jan 7, 2020·Annals of Medicine·Ahsan A KhanAlena Shantsila
Mar 29, 2020·International Journal of Molecular Sciences·Michał WicińskiBartosz Malinowski
May 30, 2020·Journal of the American Heart Association·Heng ZengJian-Xiong Chen
Jun 10, 2020·Journal of the American Heart Association·Naiara CinegagliaValeria Sandrim
Apr 15, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sana MahtabJennifer Jao
Feb 6, 2020·Experimental and Therapeutic Medicine·Zengtao WangJie Zhang
Oct 13, 2017·Molecular Nutrition & Food Research·Divya BharatPon Velayutham Anandh Babu
Apr 9, 2019·Acta Cardiologica·Camelia Cristina DiaconuOvidiu Gabriel Bratu
May 1, 2020·Oxidative Medicine and Cellular Longevity·Anna ŁuczakAdrian Doroszko
Aug 5, 2020·International Journal of Environmental Research and Public Health·Mashudu NemukulaLizette Bekker
Aug 2, 2017·International Journal of Molecular Sciences·Ding-Yuan TianYun Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
imaging technique
gastric bypass

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

Endothelium : Journal of Endothelial Cell Research
Thomas TrepelsStephan Fichtlscherer
Advances in Neuroimmunology
G L FricchioneG B Stefano
© 2021 Meta ULC. All rights reserved