Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation

British Journal of Pharmacology
Pál PacherCsaba Szabó

Abstract

Recent work has demonstrated the production of reactive oxygen and nitrogen species in the vasculature of aging animals. Oxidant induced cell injury triggers the activation of nuclear enzyme poly(ADP ribose) polymerase (PARP) leading to endothelial dysfunction in various pathophysiological conditions (reperfusion, shock, diabetes). Here we studied whether the loss of endothelial function in aging rats is dependent upon the PARP pathway within the vasculature. Young (3 months-old) and aging (22 months-old) Wistar rats were treated for 2 months with vehicle or the PARP inhibitor PJ34. In the vehicle-treated aging animals there was a significant loss of endothelial function, as measured by the relaxant responsiveness of vascular rings to acetylcholine. Treatment with PJ34, a potent PARP inhibitor, restored normal endothelial function. There was no impairment of the contractile function and endothelium-independent vasodilatation in aging rats. Furthermore, we found no deterioration in the myocardial contractile function in aging animals. Thus, intraendothelial PARP activation may contribute to endothelial dysfunction associated with aging.

References

Jun 15, 1996·Annals of the New York Academy of Sciences·M Inoue, K Inoue
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L LiaudetC Szabo
Sep 19, 2000·British Journal of Pharmacology·R L MatzR Andriantsitohaina
Oct 13, 2000·British Journal of Pharmacology·C HeymesC M Boulanger
Dec 20, 2000·The Journal of Experimental Medicine·B van der LooT F Lüscher
Aug 21, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F G SorianoC Szabó

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Citations

May 5, 2004·Respiratory Physiology & Neurobiology·Jolanta DorszewskaJózef Szczech
May 3, 2005·Nature Reviews. Drug Discovery·Prakash Jagtap, Csaba Szabó
Jun 26, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan UngvariAnna Csiszar
Jun 24, 2004·The Journal of Pharmacology and Experimental Therapeutics·Pál PacherCsaba Szabó
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pál PacherCsaba Szabó
Jul 5, 2008·Journal of Applied Physiology·Anna CsiszarZoltan Ungvari
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Nov 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Ludovica PiconiAntonio Ceriello
May 17, 2003·Drugs & Aging·Rachel L Matz, Ramaroson Andriantsitohaina
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Anna CsiszarZoltan Ungvari
Nov 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zsuzsanna TucsekZoltan Ungvari
Sep 4, 2015·Clinical and Experimental Pharmacology & Physiology·Guang-Hao ZhangQing-Hua Lu
Oct 4, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Partha MukhopadhyayPal Pacher
Jun 25, 2009·Biochemical Pharmacology·Simon G HelyarJon G Mabley
Jan 29, 2009·Medicina clínica·Carmen MingoranceMaría Alvarez De Sotomayor
Jul 22, 2009·Ageing Research Reviews·María Dolores HerreraMaria Alvarez de Sotomayor
Oct 28, 2008·Biochemical and Biophysical Research Communications·Dirk M MaybauerDaniel L Traber
Mar 28, 2013·Oxidative Medicine and Cellular Longevity·Ana-Maria EnciuBogdan O Popescu
Jul 14, 2010·BioFactors·Heibatullah Kalantari, Dipak K Das
Apr 15, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arda TasatargilGulay Sadan
Sep 3, 2011·Free Radical Biology & Medicine·Partha MukhopadhyayPál Pacher
May 21, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Takashi ShirakuraHiroaki Masuzaki
Aug 24, 2012·International Journal of Toxicology·Selvinaz DalakliogluArda Tasatargil
Apr 13, 2004·Journal of Cardiovascular Pharmacology·Tamas AlexyKalman Toth
Aug 29, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Arda TasatargilBedriniam Dalkiran
May 14, 2016·Circulation Research·Irene AlfarasRafael de Cabo
Jun 9, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Kathryn A BrownFrank M Faraci

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