Endothelial dysfunction in coronary vessels and thoracic aorta of rats exposed to cigarette smoke

Clinical and Experimental Pharmacology & Physiology
P A JorgeE A Almeida

Abstract

1. The aim of this study was to evaluate the role of endothelium in mediating the response to acetylcholine in the thoracic aorta and coronary vessels of rats exposed to cigarette smoking. Total serum cholesterol was measured at the beginning and end of the experiment. 2. The relaxation response to acetylcholine was significantly impaired in the aortae of rats exposed to cigarette smoking (P < 0.05); and the coronary flow during the administration of acetylcholine (0.02 microgram/min.) was significantly reduced (P < 0.05). The total cholesterol plasma levels increased 31.13% in those exposed to smoke when compared to the controls (P < 0.05). 3. It is concluded that exposure to cigarette smoking increases total serum cholesterol levels, and also produces primary endothelial dysfunction in aorta rings and coronary vessels.

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Citations

Dec 8, 2000·Journal of Addictive Diseases·N T Laughlin
May 23, 1998·Journal of Clinical Pharmacology·V M MillerR D Hurt
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·V M MillerR D Hurt
Sep 6, 2000·International Journal of Experimental Pathology·R Michael Pittilo
Dec 19, 2007·Asian Journal of Andrology·Kaya HorasanliCengiz Miroglu

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