Endothelial dysfunction in hemodialysis patients with failed renal transplants

Clinical Transplantation
N GorguluM S Sever

Abstract

Endothelial dysfunction (ED) is a common precursor and denominator of cardiovascular events including development of atherosclerosis. In this cross-sectional study, we aimed to investigate ED, measured by coronary flow reserve (CFR) in hemodialysis (nHD) patients who were never transplanted and patients with failed renal transplants restarting hemodialysis (fTx-HD). Forty nHD (24 males, mean age 39 ± 9 yr) and 43 fTx-HD patients (27 males, mean age 36 ± 9 yr) were included in the study. Clinical and biochemical parameters, including high-sensitive C-reactive protein (hs-CRP) levels were determined. Also, CFR measurements were used to evaluate ED. There were no significant differences regarding age, gender, smoking status, systolic and diastolic blood pressure levels, mean duration of HD treatment as well as Kt/V((urea)) values between the two groups. Time spent on dialysis in the nHD group and dialysis duration following failure of renal allograft in the fTx-HD group were similar. Serum creatinine, hemoglobin, hematocrit, calcium and phosphorus levels were similar between the two groups as well. When compared to nHD group, serum total cholesterol (139 ± 3 vs. 154 ± 3 mg/dL, p = 0.045), serum albumin (3.8 ± 0.3 g/dL vs. 4.1 ± 0....Continue Reading

References

Jul 1, 1974·The American Journal of Cardiology·K L Gould, K Lipscomb
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Jul 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C van GuldenerC D Stehouwer
Feb 13, 1999·Kidney International·J ZimmermannC Wanner
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C H BoltonJ H Pinkney
Sep 27, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P Stenvinkel
Dec 12, 2001·Clinical Transplantation·P J Smak GregoorW Weimar
Feb 19, 2002·Kidney International·Akihiko KatoAkira Hishida
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bruce Kaplan, Herwig-Ulf Meier-Kriesche
Apr 16, 2003·Kidney International. Supplement·Karin Tyralla, Kerstin Amann
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Dierk H Endemann, Ernesto L Schiffrin
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Juan M López-GómezJuan Carlos Ayus
Jun 7, 2005·Seminars in Dialysis·Anthony J Langone, Peale Chuang
Aug 23, 2005·Nephron. Clinical Practice·Derya TokHaldun Muderrisoglu
Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Huseyin KocakMurat Tuncer
Apr 1, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Huseyin OflazMehmet S Sever

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Citations

Nov 29, 2012·Hemodialysis International·Beyza MacunluogluAlla Eldeen Kedrah
Sep 11, 2013·Seminars in Dialysis·Miklos Z MolnarCsaba P Kovesdy
Jul 3, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claire T KassakianGeorge P Bayliss
Feb 18, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jennifer WilliamsAngela Shore
May 9, 2014·The International Journal of Artificial Organs·Tulin AkagunMehmet Sukru Sever

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