Endothelial dysfunction in patients with granulomatosis with polyangiitis: a case-control study

Rheumatology International
Renata PacholczakJerzy Dropiński

Abstract

Granulomatosis with polyangiitis (GPA) is a rare granulomatous vasculitis affecting small- and medium-sized blood vessels. In optimally treated patients with long-standing disease, the common cause of death is atherosclerosis even in the absence of typical risk factors. To evaluate endothelial dysfunction in GPA patients. 44 patients (21 men and 23 women) diagnosed with GPA and 53 controls matched for age, sex, BMI and typical risk factors for cardiovascular diseases (22 men and 31 women) were enrolled in the study. We measured each participant's serum levels of vascular cell adhesion molecule-1 (VCAM-1), interleukin 6 (IL-6), and thrombomodulin. We also studied flow-mediated dilatation (FMD) of the brachial artery, intima-media thickness (IMT) of the common carotid artery and aortic stiffness using echocardiography. Patients with GPA showed a 15.9% increase in serum levels of VCAM-1 (p = 0.01), 66% of IL-6 (p < 0.001) and 50.9% of thrombomodulin (p < 0.001) compared to controls. FMD% was 48.9% lower in patients with GPA in comparison to controls (p < 0.001), after adjustment for potential confounders, with no differences regarding IMT or aortic stiffness. FMD% was negatively associated with duration of the disease (β = - 0.18 ...Continue Reading

References

Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Aug 1, 1990·Journal of the American College of Cardiology·B Healy
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Apr 1, 1994·The American Journal of Physiology·Y P Wang, F Fuchs
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Folkman
Aug 17, 1999·Archives of Internal Medicine·D D AnthonyG McComsey
Sep 17, 1999·Mayo Clinic Proceedings·R D LeffC J Mullany
Feb 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ColleoniA Goldhirsch
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Mar 8, 2005·Internal Medicine·Ikuo Taniguchi
Jun 18, 2005·BMJ : British Medical Journal·Graham S Hillis, Peter Bloomfield
Aug 30, 2005·Annals of the New York Academy of Sciences·Karina de LeeuwMarc Bijl
Nov 9, 2005·Thrombosis Research·Monika StalcTanja Kveder
Apr 25, 2006·Lancet·Alexander WoywodtEric L Matteson
Mar 14, 2007·Circulation·John E DeanfieldTon J Rabelink
Jul 26, 2008·Clinical Rheumatology·Alma CypieneJonas Gintautas
Apr 1, 2009·Arthritis and Rheumatism·Mikkel FaurschouBo Baslund
Aug 7, 2009·Journal of Autoimmunity·Massimo CugnoPier Luigi Meroni
Oct 27, 2009·Rheumatology International·Bijan AhmadiMansoor Karimifar
Feb 24, 2010·Arthritis and Rheumatism·L A ClarkeP A Brogan
Apr 3, 2010·The Open Cardiovascular Medicine Journal·Giuseppe Cocco, Armen Yuri Gasparyan
Mar 20, 2013·Best Practice & Research. Clinical Rheumatology·Jan Willem Cohen Tervaert

❮ Previous
Next ❯

Citations

Aug 23, 2018·Clinical Rheumatology·Renata PacholczakJerzy Dropiński
Apr 20, 2021·Atherosclerosis·Alison H Clifford, Jan Willem Cohen Tervaert

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

STATISTICA

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.