Endothelial dysfunction in preeclampsia

Seminars in Reproductive Endocrinology
J M Roberts

Abstract

Several years ago the hypothesis was advanced that alterations of endothelial function could explain much of the pathophysiology of preeclampsia. Since that time, extensive data have been generated to support the hypothesis. Markers of endothelial activation can be demonstrated in women with overt preeclampsia. More importantly, many of these markers precede clinically evident disease and disappear with resolution of the disease. The original postulate was that materials produced by the poorly perfused placenta, which is characteristic of preeclampsia, entered the systemic circulation and altered endothelial cell activity. This was proposed to change vascular sensitivity to circulating pressors, activate coagulation, and reduce vascular integrity resulting in the pathophysiological changes of preeclampsia. As data have accumulated it has become increasingly evident that the insult to the endothelium is neither toxicity nor nonspecific injury but rather can better be characterized as endothelial activation. Candidate molecules have been suggested but not established. It seems likely that the responsible agent(s) will not be unique molecules but rather usual molecules present in excessive amounts. The hypothesis has been expanded...Continue Reading

Citations

Jun 10, 2011·Current Hypertension Reports·Catherine M Brown, Vesna D Garovic
Mar 16, 2004·Seminars in Nephrology·Ursula QuittererSaid Abdalla
Jul 10, 2003·Clinical Biochemistry·Abdelaziz KharfiJean-Claude Forest
Mar 29, 2001·Obstetrics and Gynecology·R ThadhaniF D Frigoletto
Nov 13, 2001·Obstetrics and Gynecology·M WolfR Thadhani
Sep 29, 2001·Obstetrics and Gynecology·J M Roberts
Oct 18, 2002·Obstetrics and Gynecology·Scott KaumaThomas Peng
Feb 11, 2003·Obstetrics and Gynecology·R Phillip HeineJames M Roberts
May 10, 2003·Obstetrics and Gynecology·Brian TrudingerJun Wang
Feb 16, 2000·Obstetrics and Gynecology·M T RaijmakersW H Peters
Oct 29, 2002·Lancet·Richard E LeachD Randall Armant
Mar 7, 2001·Regulatory Peptides·N M PageP J Lowry
Jan 4, 2001·Human Immunology·M O'BrienP Moreau
Sep 15, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E Gratacós
Apr 13, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M E SpaandermanL L Peeters
Apr 13, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M T RaijmakersW H Peters
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F ScaleraE Beinder
Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luís BeloIrene Rebelo
Aug 21, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·S K Smith
Jul 25, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Merja VainioJohanna Mäenpää
Feb 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wen-long GaoYan-ling Wang
Sep 21, 2013·Journal of Human Hypertension·K H LampinenR J Kaaja
Jun 14, 2002·Placenta·J M Roberts, K Y Lain
Dec 9, 2010·Cardiovascular Research·Tereza Cindrova-DaviesD Stephen Charnock-Jones
Jan 24, 2009·Biology of Reproduction·Shawn P MurphyB Anne Croy
Jul 14, 2000·BMJ : British Medical Journal·D Carnall
Nov 18, 2004·Heart·P Rachael James, Catherine Nelson-Piercy
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Graham W AberdeenEugene D Albrecht
Nov 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sydney R MurphyJoey P Granger
Jun 12, 2012·Journal of Pregnancy·Reem MustafaRocco C Venuto
Feb 6, 2009·American Journal of Nephrology·Mohammad N UddinJules B Puschett
May 25, 2011·Hypertension·Caroline S EvansSanjeev G Shroff
Jan 12, 2008·Reproductive Sciences·Robert W PowersJames M Roberts
Mar 17, 2010·Reproductive Sciences·Jonathan D LeavenworthDonald S Torry
Jan 16, 2010·Reproductive Biology and Endocrinology : RB&E·Nigel M Page

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