Endothelial dysfunction in pregnancy metabolic disorders

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Cesar EcheverriaFelipe Simon

Abstract

In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.

References

Jan 15, 1979·American Journal of Obstetrics and Gynecology·J M Potter, P J Nestel
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·G DesoyeG M Kostner
Apr 1, 1985·American Journal of Obstetrics and Gynecology·D CavanaghJ U Balis
Apr 5, 1980·British Medical Journal·D Ikedife
Mar 1, 1993·The Journal of Clinical Investigation·Y ZhouS J Fisher
Feb 1, 1995·Pharmacology & Therapeutics·L PostonJ M Ritter
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R L Kendall, K A Thomas
Jun 1, 1993·Seminars in Cell Biology·S J Fisher, C H Damsky
Mar 1, 1993·British Journal of Obstetrics and Gynaecology·J T UotilaM O Ahotupa
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Mar 1, 1997·Reproductive Toxicology·Ch DamskyS Fisher
Jun 3, 1998·American Journal of Obstetrics and Gynecology·E GratacósA Fortuny
Apr 2, 1999·Seminars in Perinatology·L Myatt, M Miodovnik
Dec 10, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R MadazliF Aksu
Feb 5, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Ware-JaureguiM A Williams
Feb 5, 2000·Journal of Reproductive Immunology·P TubbergenG A Dekker
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R FigueroaM S Wolin
Apr 12, 2000·Acta Physiologica Scandinavica·U PohlT Gloe
Jun 2, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·M M Müller, A Griesmacher
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
Sep 15, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E Gratacós
Feb 24, 2001·Lancet·J M Roberts, D W Cooper
Apr 13, 2001·JAMA : the Journal of the American Medical Association·J C ChambersJ S Kooner
Oct 23, 2002·Clinical Endocrinology·V ToescuF Dunne

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Citations

Aug 1, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Philippe VangriekenPaul M H Schiffers
Mar 11, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yujing He, Na Wu

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