Endothelial dysfunction in rheumatoid arthritis: influence of HLA-DRB1 alleles

Autoimmunity Reviews
Miguel A Gonzalez-GayWilliam E Ollier

Abstract

Cardiovascular disease is the commonest cause of premature mortality in rheumatoid arthritis (RA) patients. Vascular endothelial injury is the primary event in atherosclerosis. It has been associated with endothelial dysfunction. We have recently observed that actively treated RA patients had endothelial dysfunction. HLA-DRB1 shared epitope alleles, in particular HLA-DRB1*0404, seem to be implicated in the development of endothelial dysfunction. These results underline the influence of genetic factors in the risk of atherosclerosis in RA patients.

References

Aug 1, 1986·Annals of the Rheumatic Diseases·D JaraquemadaR N Maini
May 1, 1984·British Journal of Rheumatology·P PriorC F Hawkins
Oct 1, 1994·Annals of the Rheumatic Diseases·P A Bacons, G D Kitas
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Nov 26, 1999·Circulation·V Pasceri, E T Yeh
Nov 21, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A D Blann

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Citations

Sep 11, 2010·Expert Review of Cardiovascular Therapy·Elena BartoloniRoberto Gerli
Oct 9, 2009·Clinical and Experimental Hypertension : CHE·Vasileios F PanoulasGeorge D Kitas
Jun 15, 2010·Autoimmunity Reviews·Elena BartoloniRoberto Gerli
Oct 9, 2009·Journal of Autoimmunity·Veena Taneja, Chella S David
Apr 9, 2008·Seminars in Arthritis and Rheumatism·Adriana Rojas-VillarragaJuan-Manuel Anaya
Apr 9, 2008·Seminars in Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Llorca
Aug 29, 2012·Mediators of Inflammation·Luis Rodríguez-RodríguezJavier Martín
Oct 20, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Miguel A Gonzalez-GayJavier Martin
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Martin
Apr 28, 2009·Autoimmunity Reviews·Michael T Nurmohamed
Nov 30, 2012·Arthritis·Juan Camilo Sarmiento-MonroyAdriana Rojas-Villarraga
Sep 2, 2014·BioMed Research International·Jenny Amaya-AmayaAdriana Rojas-Villarraga
Feb 22, 2012·Nature Reviews. Rheumatology·György KerekesZoltán Szekanecz
May 23, 2018·QJM : Monthly Journal of the Association of Physicians·Mohamad AdawiArnon Blum
Jan 18, 2011·The Journal of Rheumatology·Nóra BodnárSándor Szántó

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