Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A

Journal of the American Heart Association
Tatsuya MaruhashiYukihito Higashi

Abstract

The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow-up period of 49.2 months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver-operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06-0.74; P=0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09-0.79; P=0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01-3.44; P=0.04) and second (hazard ra...Continue Reading

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Citations

Jan 9, 2019·Metabolic Syndrome and Related Disorders·Do Kyung Kim, Won Hah Park
Mar 29, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Masato KajikawaYukihito Higashi
Dec 12, 2019·Journal of the American Heart Association·Hirofumi TomiyamaAkira Yamashina
Sep 17, 2020·Clinical Science·Yoshito Yamashiro, Hiromi Yanagisawa
Aug 13, 2020·Biomedicines·Jessica GambardellaValentina Trimarco
May 16, 2019·American Journal of Hypertension·Tatsuya MaruhashiYukihito Higashi
Apr 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotoshi Ohmura
Jul 25, 2019·International Journal of Molecular Sciences·Isabella Viana Gomes SilvaDanyelle Romana Alves Rios
Feb 6, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji MizunoHirofumi Yasue
Sep 23, 2020·Cardiovascular Engineering and Technology·Sheldon WeinbaumJohn M Tarbell
Oct 26, 2018·Hypertension·Atsushi TanakaUNKNOWN Physiological Diagnosis Criteria for Vascular Failure Committee
Feb 25, 2021·Journal of Food Biochemistry·Fernando Guerrero-RomeroClaudia I Gamboa-Gómez
Apr 16, 2020·Critical Reviews in Food Science and Nutrition·Banafsheh Jafari AzadAndriko Palmowski
Dec 24, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Vicki VaniaGuixue Wang
Apr 18, 2021·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Marko NovakovićBorut Jug
May 20, 2021·Journal of Clinical Lipidology·Yuji TakaekoYukihito Higashi
Jul 18, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takayuki YamajiYukihito Higashi
Dec 29, 2020·Journal of Atherosclerosis and Thrombosis·Masato Kajikawa, Yukihito Higashi
Dec 10, 2021·Frontiers in Cardiovascular Medicine·Jianning ZhangJun Tao
Dec 24, 2021·Journal of Atherosclerosis and Thrombosis·Tatsuya MaruhashiYukihito Higashi

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Methods Mentioned

BETA
coronary bypass

Software Mentioned

Stata
JMP

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