Endothelial Dysfunction Is Associated with Cognitive Impairment of Elderly Cardiovascular Disease Patients

International Heart Journal
Kazuhiro FujiyoshiJunya Ako

Abstract

Cognitive impairment is frequently represented in elderly patients with cardiovascular disease (CVD); yet, the mechanism is uncertain. Recent studies have suggested the association between the vascular endothelial dysfunction and cognitive impairment. The aim of this study was to clarify the association between endothelial dysfunction and cognitive impairment in elderly patients with CVD.A total of 80 elderly patients (> 70 years old) with CVD were included. Patients who had already pharmacologically intervened for cognitive impairment were excluded. The endothelial dysfunction was assessed by the reactive hyperemia-peripheral arterial tonometry (RH-PAT). Cognitive impairment was diagnosed by the Mini-mental state examination.The RH-PAT index was significantly lower in cognitive impairment (median 1.60 [interquartile range (IQR) 1.34 to 1.89], n = 51) as compared with non-cognitive impairment (median 1.75 [IQR 1.55 to 2.30], n = 29, P = 0.005). By a multivariate analysis, the RH-PAT index was independently associated with cognitive impairment (odds ratio: 0.89; 95% confidence interval: 0.81 to 0.97; per 0.1, P = 0.044). In the receiver-operating characteristic analysis, the best cut-off of the RH-PAT index to identify cognitive...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 12, 2001·Neurology·G ZuccalàUNKNOWN GIFA-ONLUS Study Group [Grupo Italiano di Farmacoepidemiologia nell'Anzanio]
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·J C de la Torre
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Donald R Royall
Nov 6, 2002·Journal of the Neurological Sciences·Gustavo C Román
May 28, 2003·Journal of the American College of Cardiology·Piero O BonettiAmir Lerman
Jul 10, 2003·American Heart Journal·Jeffrey T KuvinJames E Udelson
May 19, 2004·Archives of Neurology·Christiane ReitzRichard Mayeux
Jul 13, 2005·Archives of Neurology·Ronald C Petersen, John C Morris
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
May 16, 2008·International Journal of Clinical Practice·Y SuY Luan
Feb 3, 2009·Journal of Cardiac Failure·Mary Jane SauvéSusan J Pressler
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Rachel A WhitmerJoseph V Selby
Apr 17, 2010·Journal of the American College of Cardiology·Yasushi MatsuzawaHisao Ogawa
Jul 22, 2011·Lancet Neurology·Deborah E Barnes, Kristine Yaffe
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Sep 2, 2011·The American Journal of Cardiology·Angela L JeffersonEmelia J Benjamin
May 4, 2012·European Heart Journal·Martin O'DonnellSalim Yusuf
Jun 12, 2012·Heart Failure Reviews·Viviane M ConraadsChristiaan J Vrints
Aug 7, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pasquale SantangeliAndrea Natale
Jun 7, 2013·Aging Clinical and Experimental Research·Gianluigi VendemialeGaetano Serviddio
Apr 29, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki SuzukiKazuo Kimura
Aug 12, 2014·Ageing Research Reviews·Pasquale AbeteFrancesco Cacciatore

❮ Previous
Next ❯

Citations

Jul 25, 2019·Stroke and Vascular Neurology·Feng Han
May 8, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Camilla Maroni Marques Freire de MedeirosAlexandre Braga Libório
Jul 25, 2019·Current Pharmaceutical Design·Kazuo Yamagata
Jun 17, 2020·Journal of Alzheimer's Disease : JAD·Cameron Isaacs-TrepanierKrista L Lanctôt
Mar 31, 2021·ESC Heart Failure·Angela S Koh, Jean-Paul Kovalik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.