Endothelial function and bradykinin in humans

Drugs
B Hornig, H Drexler

Abstract

The endothelium controls vascular smooth muscle tone by secreting relaxing and contracting factors. There is a constant release of endothelium-derived relaxing factors (EDRFs) under basal conditions. In addition, the endothelium can increase the release of EDRFs in response to humoral stimulation by vasoactive substances such as acetylcholine or bradykinin. Under physiological conditions, the most important stimulus to the release of EDRFs is an increase in blood flow leading to increased shear stress on endothelial cells. Recent experimental studies raised the possibility that bradykinin plays an important role in the regulation of vascular tone at rest and during flow-stimulated conditions. Bradykinin is a very potent vasodilator that exerts its vasodilatory actions by causing endothelial release of nitric oxide, prostacyclin and/or a hyperpolarising factor [endothelium-derived hyperpolarising factor (EDHF)]. This concept is also supported by recent studies in humans demonstrating that bradykinin contributes to the regulation of coronary vascular tone under resting and flow-stimulated conditions. This mechanism has now been shown to be important in both human peripheral and coronary arteries. Angiotensin converting enzyme (AC...Continue Reading

Citations

Jun 13, 2001·Journal of the American College of Cardiology·M E KhalilI A Alhaddad
Jan 15, 2000·Journal of the American College of Cardiology·P C Deedwania
Feb 28, 2002·British Journal of Pharmacology·G F Baxter, Z Ebrahim
Apr 7, 2007·American Journal of Therapeutics·María Cristina Armas-PadillaManuel Valasco
Jan 18, 2006·Acta Pharmacologica Sinica·Chun-guang Chen, Yi-ping Wang
Sep 26, 2009·Journal of Cellular Physiology·Veronica BovenziFernand Gobeil
Nov 7, 2001·The American Journal of Pathology·W C WolfJ Chao
Jan 5, 2012·The American Journal of Pathology·Justin F DenisetGrant N Pierce
Mar 26, 2003·QJM : Monthly Journal of the Association of Physicians·A-Y ChongG Y H Lip
Jan 16, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W C WolfJ Chao
Apr 16, 2003·Hypertension·Michael VetterChung-Ho Chang
Nov 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Mikhail Y MaslovMark A Lovich
May 16, 2020·Journal of Clinical Pathology·Łukasz PawlińskiBeata Kieć-Wilk
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H ParfenovaC W Leffler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.