Endothelial function in children with a history of premature prolonged rupture of membranes and bronchopulmonary dysplasia--a pilot study

Acta Paediatrica
Magnus LiljedahlJens Schollin

Abstract

To investigate vascular function in children with a neonatal history of generalised inflammation indicated by premature prolonged rupture of membranes (PPROM) and bronchopulmonary dysplasia (BPD). Children born at <or=30 weeks 1994-2000 were investigated at a present age of 6-12 years. Twenty-eight children participated and were divided into two groups with regard to BPD/no BPD (n=15/13) and PPROM/no PPROM (n=10/18). Vascular endothelial function was assessed by acetylcholine (ACh)-induced skin vasodilatation. Maximum ACh-induced skin perfusion was statistically significantly lower in the PPROM group compared with the non-PPROM group (p=0.045) after adjustment for confounders. We found no association between BPD and maximum ACh-induced skin perfusion (p=0.404), after adjustment for confounders. A neonatal history of prolonged premature rupture of membranes was associated with later impairment of vascular endothelial function in childhood. This association was not observed with BPD. Some forms of perinatal inflammation may be associated with later cardiovascular function.

References

Jan 1, 1989·Acta Anatomica·R DemirA Kotowski
Aug 1, 1986·Journal of Applied Physiology·G J SmitsJ H Lombard
May 28, 1988·British Medical Journal·G GennserP E Isberg
Oct 1, 1980·IEEE Transactions on Bio-medical Engineering·G E NilssonP A Oberg
Dec 1, 1994·The Journal of Clinical Investigation·K O KleinG B Cutler
Jan 1, 1995·Reproduction, Fertility, and Development·I Huhtaniemi
Aug 15, 1998·American Journal of Obstetrics and Gynecology·R RomeroS M Berry
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·P LassusS Andersson
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wulf Palinski, Claudio Napoli
Nov 20, 2002·American Journal of Obstetrics and Gynecology·Sean S DaneshmandLjubica Bogic
Mar 30, 2004·Acta Paediatrica·Magnus LiljedahlJ Schollin
May 21, 2004·Pediatric Research·James D Cherry, Paul Krogstad
Aug 24, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suhas G KallapurAlan H Jobe
Jun 11, 2005·Science·Michael E Mendelsohn, Richard H Karas
Jun 3, 2006·Pediatrics·Vineet BhandariUNKNOWN Neonatal Genetics Study Group

❮ Previous
Next ❯

Citations

Mar 23, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Geraldine F Clough, Mikael Norman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.