Endothelial growth factor receptor-targeted and reactive oxygen species-responsive lung cancer therapy by docetaxel and resveratrol encapsulated lipid-polymer hybrid nanoparticles

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zizheng SongGuanghai Dai

Abstract

Special targeted therapy like endothelial growth factor receptor (EGFR) targeted therapy is available for the treatment of advanced non-small cell lung cancer (NSCLC). Biodegradable core-shell lipid-polymer hybrid nanoparticles (LPNs) can combine the beneficial properties of lipid and polymeric NPs for controlled drug delivery. In the present study, epidermal growth factor (EGF) conjugated LPNs were fabricated to co-deliver docetaxel (DTX) and resveratrol (RSV). In vitro and in vivo studies demonstrated that EGF DTX/RSV LPNs have significant synergistic effects, best tumor inhibition ability and the lowest systemic toxicity. The results indicate that EGF DTX/RSV LPNs may be a promising strategy for treatment of NSCLC.

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Citations

Jul 28, 2019·Antioxidants·Sebastiano IntagliataLucia Montenegro
Mar 4, 2021·Cancer Reports·Manjusha AnnajiR Jayachandra Babu
Apr 20, 2021·Frontiers in Oncology·María Zenaida Saavedra-LeosMacrina Beatriz Silva-Cázares
Jun 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinglong FanJun Wang
Jul 18, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Saikat GhoshSubhas Bhowmick
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