Endothelial haemostatic markers in members of families with familial combined hyperlipidemia

Thrombosis Research
David KarásekDalibor Novotný

Abstract

The aim of this study was to evaluate the plasma levels of endothelial haemostatic markers - von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and soluble thrombomodulin (sTM) - in asymptomatic, nonsmoking members of families with familial combined hyperlipidemia (FCH). We investigated the association between these factors and the intima-media thickness (IMT) of the common carotid artery, selected risk factors of atherosclerosis and markers of insulin resistance. 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first-degree relatives, n=47) and NL (normolipidemic first-degree relatives, n=35). The control groups C-HL (n=20) and C-NL (n=20) consisted of sex- and age-matched healthy individuals. IMT was measured by ultrasound at a far wall of both common carotid arteries. Compared with healthy controls, hyperlipidemic subjects had significantly higher levels of vWF (146.4+/-73.2% versus 112.2+/-29.4%, p<0.05), of PAI-1 (102.4[83.0-117.0] ng/ml versus 63.5[31.8-87.3] ng/ml, p<0.01) and of t-PA (5.1[2.5-7.9] ng/ml versus 3.4[1.4-5.8] ng/ml, p<0.05). They had increased IMT, which correlated with vWF (r=0.29, p<0.05). Their normolipid...Continue Reading

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Citations

Jun 17, 2010·Journal of Atherosclerosis and Thrombosis·Mathias T GrebeDursun Gündüz
Jul 20, 2010·Journal of Thrombosis and Thrombolysis·David KarasekDalibor Novotny
May 13, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dalibor NovotnyLudek Slavik
Apr 25, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mikael EkholmN Håkan Wallén
Sep 21, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ruibin FuJian Qiu
Aug 22, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Arturo CarratalaJuan F Ascaso
Sep 5, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mikael EkholmN Håkan Wallén

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