PMID: 9438555Jan 23, 1998Paper

Endothelial injury from a circulating mediator following rat liver ischemia

Free Radical Biology & Medicine
S TanD A Parks

Abstract

Ischemia-reperfusion to the liver results in increased microvascular permeability in a nonischemic lung. We hypothesized that a circulatory mediator released from ischemic liver contributed to endothelial cell (EC) damage. Isolated rat livers, made ischemic for 2 h, were reperfused for 10 min. Bovine ECs were incubated for 5 h with pooled liver effluent collected before ischemia (Baseline) or after 10 min of reperfusion (Reperfusion). In the Reperfusion group, there was increased endothelial cell injury, as determined by release of 8-[14C]adenine, (39 +/- 2%) compared to the Baseline group (22 +/- 2%). Permeability of ECs to rhodamine B-labeled dextran (70,000 Mr) was also increased in the Reperfusion group by 54 +/- 9%. There was no significant attenuation in EC injury following incubation with reperfusion effluent stored for 24 h, supplementation with antioxidants (superoxide dismutase + catalase), or inhibition of xanthine oxidase with allopurinol or tungstate. We conclude that the reperfused liver releases a long-lived circulatory mediator of EC injury, which may produce the clinical microvascular injury observed following hepatic ischemia. The mechanism of injury in our model is independent of oxidants or oxidants generate...Continue Reading

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Citations

Mar 21, 2000·Life Sciences·S M Bailey, L A Reinke
Jan 18, 2006·Treatments in Respiratory Medicine·Melpo Christofidou-Solomidou, Vladimir R Muzykantov
Feb 9, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Luiz Eduardo Correia MirandaPaulo Roberto Barbosa Evora
May 21, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Takashi ShirakuraHiroaki Masuzaki
Nov 4, 2000·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Q Shi
Jan 9, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Katsutaka WatanabeMasato Nagino

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