Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin

Ultrastructural Pathology
S KohnE Robinson

Abstract

The drugs cisplatin and gentamicin are used for treatment of various cancer patients suffering from infection. The authors report a detailed electron microscopic study of blood vessels in stria vascularis of guinea pigs after treatment with cisplatin alone and in combination with gentamicin. The most distinctive features expressing endothelial cellular injury were mitochondrial, including occasional paracrystalline inclusions; electron-lucent foci with depleted organelles; intracytoplasmic vacuole formations; lipid bodies; cytoplasmic extrusions located on the luminal surface; and severe luminal constriction of part of the vessels from animals treated with the combined drugs. The study suggests that the damage to strial capillaries due to treatment with cisplatin alone and in combination with gentamicin may contribute to the injurious effects of these drugs on the strial tissue. Furthermore, the results of this study may enlarge the awareness of the potential vascular damage and vascular complications in additional body systems after medical use of cisplatin alone or in combination with gentamicin.

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Citations

Sep 6, 2005·Cell Biology and Toxicology·B L'AzouL Bordenave
Oct 4, 2002·Hearing Research·Francisca L C WoltersGuido F Smoorenburg
Nov 27, 1999·Hearing Research·K C CampbellL F Hughes
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Apr 16, 2014·Vascular Pharmacology·Minmin ZhuChanghong Miao
Jul 21, 2005·Ultrastructural Pathology·Sarah KohnTheodore C Iancu
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Apr 28, 2005·Hearing Research·Natalie L M CappaertGuido F Smoorenburg
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Jun 3, 2021·Journal of Personalized Medicine·Archana RamgopalRamasubramanian Kalpatthi
Aug 14, 2021·Ageing Research Reviews·Dorit Samocha-BonetDavid K Ryugo

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