Endothelial membrane reorganization during leukocyte extravasation.

Cellular and Molecular Life Sciences : CMLS
Natalia Reglero-RealJaime Millán

Abstract

Leukocyte trafficking from the bloodstream to inflamed tissues across the endothelial barrier is an essential response in innate immunity. Leukocyte adhesion, locomotion, and diapedesis induce signaling in endothelial cells and this is accompanied by a profound reorganization of the endothelial cell surfaces that is only starting to be unveiled. Here we review the current knowledge on the leukocyte-mediated alterations of endothelial membrane dynamics and their role in promoting leukocyte extravasation. The formation of protein- and lipid-mediated cell adhesion nanodomains at the endothelial apical surface, the extension of micrometric apical membrane docking structures, which are derived from microvilli and embrace adhered leukocytes, as well as the vesicle-trafficking pathways that are required for efficient leukocyte diapedesis, are discussed. The coordination between these different endothelial membrane-remodeling events probably provides the road map for transmigrating leukocytes to find exit points in the vessel wall, in a context of severe mechanical and inflammatory stress. A better understanding of how vascular endothelial cells respond to immune cell adhesion should enable new therapeutic strategies to be developed th...Continue Reading

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Citations

Dec 25, 2012·Molecular Biology of the Cell·Juan F ArandaJaime Millán
Jun 27, 2014·Molecular Biology of the Cell·Gareth W FearnleySreenivasan Ponnambalam
Sep 23, 2014·Cell Reports·Natalia Reglero-RealJaime Millán
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Oct 28, 2017·International Journal of Molecular Sciences·Takayuki Okamoto, Koji Suzuki
Aug 16, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Natalia Reglero-RealSussan Nourshargh
Jul 16, 2017·Biochemical Society Transactions·Jonas FranzChristoph Riethmüller
Apr 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael Schnoor
Dec 16, 2018·Cellular and Molecular Life Sciences : CMLS·Natalia Colás-Algora, Jaime Millán
Jan 1, 2020·Journal of Vascular Surgery. Vascular Science·Yutaka MatsubaraAlan Dardik

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